FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014377847> ?p ?o ?g. }

• W2014377847 endingPage "429" @default.
• W2014377847 startingPage "422" @default.
• W2014377847 abstract "Immunization of young children with the oral inactivated whole cell cholera vaccine Dukoral((R)) containing recombinant cholera toxin B subunit (CTB) induces antibody responses which can be further enhanced by zinc supplementation. We have investigated if immunization with the cholera vaccine induces specific T-cell responses in young children and also whether zinc supplementation influences these responses. Bangladeshi children (10-18 months old) received vaccine alone, vaccine together with zinc supplementation or only zinc. T-cell blast formation indicating a proliferative response was analyzed by the flow cytometric assay of cell-mediated immune response in activated whole blood (FASCIA) and cytokines were measured by ELISA. Stronger T-cell responses were detected if a modified CTB molecule (mCTB) with reduced binding to GM1 ganglioside was used for cell stimulation compared to normal CTB. After vaccination, CD4+ T cells responded to mCTB with significantly increased blast formation (P<0.01) and IFN-gamma production (P<0.05) compared to before vaccination. No responses to mCTB were detected in children receiving zinc alone (P>0.05). The IFN-gamma production was significantly higher (P<0.01) but the blast formation comparable (P>0.05) in children receiving zinc plus vaccine compared to in children receiving vaccine alone. The vibriocidal antibody responses induced by the vaccine were also significantly higher in children receiving zinc supplementation (P<0.001). Our results thus show that oral cholera vaccination induces a Th1 T-cell response in young children, and that the IFN-gamma as well as the vibriocidal antibody responses can be enhanced by zinc supplementation." @default.
• W2014377847 created "2016-06-24" @default.
• W2014377847 creator A5013187415 @default.
• W2014377847 creator A5018908186 @default.
• W2014377847 creator A5036325074 @default.
• W2014377847 creator A5058261078 @default.
• W2014377847 creator A5079250408 @default.
• W2014377847 date "2009-12-01" @default.
• W2014377847 modified "2023-10-07" @default.
• W2014377847 title "CD4+ T-cell responses to an oral inactivated cholera vaccine in young children in a cholera endemic country and the enhancing effect of zinc supplementation" @default.
• W2014377847 cites W1791310797 @default.
• W2014377847 cites W1882949371 @default.
• W2014377847 cites W1919984851 @default.
• W2014377847 cites W1938461180 @default.
• W2014377847 cites W1943892906 @default.
• W2014377847 cites W1991971544 @default.
• W2014377847 cites W2002855771 @default.
• W2014377847 cites W2007583102 @default.
• W2014377847 cites W2008019436 @default.
• W2014377847 cites W2009502339 @default.
• W2014377847 cites W2013167867 @default.
• W2014377847 cites W2018747439 @default.
• W2014377847 cites W2021303561 @default.
• W2014377847 cites W2023947892 @default.
• W2014377847 cites W2033568629 @default.
• W2014377847 cites W2034832824 @default.
• W2014377847 cites W2037409257 @default.
• W2014377847 cites W2045891188 @default.
• W2014377847 cites W2057205979 @default.
• W2014377847 cites W2066906970 @default.
• W2014377847 cites W2068030346 @default.
• W2014377847 cites W2077762944 @default.
• W2014377847 cites W2079871630 @default.
• W2014377847 cites W2087155029 @default.
• W2014377847 cites W2090075451 @default.
• W2014377847 cites W2091590750 @default.
• W2014377847 cites W2091969745 @default.
• W2014377847 cites W2092534266 @default.
• W2014377847 cites W2101101987 @default.
• W2014377847 cites W2107973462 @default.
• W2014377847 cites W2110004346 @default.
• W2014377847 cites W2110745296 @default.
• W2014377847 cites W2111114134 @default.
• W2014377847 cites W2114120980 @default.
• W2014377847 cites W2115338359 @default.
• W2014377847 cites W2126576666 @default.
• W2014377847 cites W2126746612 @default.
• W2014377847 cites W2131609674 @default.
• W2014377847 cites W2143968201 @default.
• W2014377847 cites W2149895303 @default.
• W2014377847 cites W2152242641 @default.
• W2014377847 cites W2156408870 @default.
• W2014377847 cites W2156644464 @default.
• W2014377847 cites W2166880878 @default.
• W2014377847 cites W2167632261 @default.
• W2014377847 cites W2170063833 @default.
• W2014377847 cites W4301655136 @default.
• W2014377847 doi "https://doi.org/10.1016/j.vaccine.2009.10.032" @default.
• W2014377847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19837094" @default.
• W2014377847 hasPublicationYear "2009" @default.
• W2014377847 type Work @default.
• W2014377847 sameAs 2014377847 @default.
• W2014377847 citedByCount "31" @default.
• W2014377847 countsByYear W20143778472012 @default.
• W2014377847 countsByYear W20143778472013 @default.
• W2014377847 countsByYear W20143778472014 @default.
• W2014377847 countsByYear W20143778472015 @default.
• W2014377847 countsByYear W20143778472016 @default.
• W2014377847 countsByYear W20143778472018 @default.
• W2014377847 countsByYear W20143778472020 @default.
• W2014377847 countsByYear W20143778472023 @default.
• W2014377847 crossrefType "journal-article" @default.
• W2014377847 hasAuthorship W2014377847A5013187415 @default.
• W2014377847 hasAuthorship W2014377847A5018908186 @default.
• W2014377847 hasAuthorship W2014377847A5036325074 @default.
• W2014377847 hasAuthorship W2014377847A5058261078 @default.
• W2014377847 hasAuthorship W2014377847A5079250408 @default.
• W2014377847 hasConcept C126322002 @default.
• W2014377847 hasConcept C159047783 @default.
• W2014377847 hasConcept C159654299 @default.
• W2014377847 hasConcept C203014093 @default.
• W2014377847 hasConcept C22070199 @default.
• W2014377847 hasConcept C2776090121 @default.
• W2014377847 hasConcept C2777006276 @default.
• W2014377847 hasConcept C2777047711 @default.
• W2014377847 hasConcept C2778643871 @default.
• W2014377847 hasConcept C2780722889 @default.
• W2014377847 hasConcept C2780801004 @default.
• W2014377847 hasConcept C523546767 @default.
• W2014377847 hasConcept C54355233 @default.
• W2014377847 hasConcept C71924100 @default.
• W2014377847 hasConcept C86803240 @default.
• W2014377847 hasConcept C8891405 @default.
• W2014377847 hasConceptScore W2014377847C126322002 @default.
• W2014377847 hasConceptScore W2014377847C159047783 @default.
• W2014377847 hasConceptScore W2014377847C159654299 @default.
• W2014377847 hasConceptScore W2014377847C203014093 @default.
• W2014377847 hasConceptScore W2014377847C22070199 @default.

• next