FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014378729> ?p ?o ?g. }

• W2014378729 endingPage "792" @default.
• W2014378729 startingPage "786" @default.
• W2014378729 abstract "Aminobisphosphonates inhibit bone resorption but have been shown to elicit acute-phase-like elevations in interleukin-6 (IL-6) in bone in vitro. The current studies were carried out to determine the relationship between the antiresorptive effects of the aminobisphosphonate alendronate and its effects on IL-6. Resorption was elicited in cultured 19-day fetal rat limb bones by 72 h treatment with interleukin-1beta (IL-1beta). Bone mass was quantitated at the end of the culture period to assess resorption. IL-6 was determined by bioassay (7TD1 cell proliferation). IL-1beta (18 and 180 pM) stimulated bone resorption and increased IL-6. Alendronate (70 microM) inhibited the IL-1beta-stimulated resorption. Alendronate alone did not affect IL-6 production by the bones. The IL-6 production from bones stimulated with 18 pM IL-1beta was not significantly affected by alendronate, but the IL-6 production from bones stimulated with 180 pM IL-1beta plus alendronate (21 and 70 microM) was higher than with IL-1beta alone. Indomethacin (1 mM) inhibited the IL-6 increase elicited by 180 pM IL-1beta and the enhanced IL-6 production elicited by cotreatment with IL-1beta and alendronate. Since bone cultures contain multiple cell types, further experiments were carried out to determine whether alendronate could increase IL-1beta-stimulated IL-6 production in an osteoblast cell line, UMR-106. Alendronate alone did not affect IL-6 in UMR-106 cells. Alendronate (70 microM) in combination with IL-1beta (180, 1.8, or 8 nM), or 7 microM alendronate, in combination with 8 nM IL-1beta, significantly increased IL-6 in 48 h cell cultures. The results from the bone organ cultures show that alendronate can enhance IL-6 production elicited by higher concentrations of the cytokine IL-1beta in bone, but that this effect on IL-6 does not prevent the inhibitory actions of alendronate on bone resorption. The results with the UMR106 cells indicate that one cellular site at which this enhancement of IL-6 production can occur is the osteoblast." @default.
• W2014378729 created "2016-06-24" @default.
• W2014378729 creator A5026523592 @default.
• W2014378729 creator A5049886691 @default.
• W2014378729 creator A5057928016 @default.
• W2014378729 creator A5072809437 @default.
• W2014378729 date "1998-05-01" @default.
• W2014378729 modified "2023-10-18" @default.
• W2014378729 title "Alendronate/Interleukin-1β Cotreatment Increases Interleukin-6 in Bone and UMR-106 Cells: Dose Dependence and Relationship to the Antiresorptive Effect of Alendronate" @default.
• W2014378729 cites W1763483366 @default.
• W2014378729 cites W1855316965 @default.
• W2014378729 cites W1855737037 @default.
• W2014378729 cites W1970789341 @default.
• W2014378729 cites W1973053335 @default.
• W2014378729 cites W1994414479 @default.
• W2014378729 cites W1996593783 @default.
• W2014378729 cites W2002986403 @default.
• W2014378729 cites W2003083329 @default.
• W2014378729 cites W2006021879 @default.
• W2014378729 cites W2006953927 @default.
• W2014378729 cites W2017707906 @default.
• W2014378729 cites W2024479120 @default.
• W2014378729 cites W2041703759 @default.
• W2014378729 cites W2043175126 @default.
• W2014378729 cites W2045503353 @default.
• W2014378729 cites W2045561085 @default.
• W2014378729 cites W2047888347 @default.
• W2014378729 cites W2049408025 @default.
• W2014378729 cites W2050268374 @default.
• W2014378729 cites W2050858140 @default.
• W2014378729 cites W2050980203 @default.
• W2014378729 cites W2053625475 @default.
• W2014378729 cites W2054526986 @default.
• W2014378729 cites W2060803891 @default.
• W2014378729 cites W2060921473 @default.
• W2014378729 cites W2064264428 @default.
• W2014378729 cites W2070333621 @default.
• W2014378729 cites W2073024058 @default.
• W2014378729 cites W2073141330 @default.
• W2014378729 cites W2073788939 @default.
• W2014378729 cites W2076661068 @default.
• W2014378729 cites W2101723917 @default.
• W2014378729 cites W2102099300 @default.
• W2014378729 cites W2122248986 @default.
• W2014378729 cites W2142229422 @default.
• W2014378729 cites W2148983446 @default.
• W2014378729 cites W2169758044 @default.
• W2014378729 cites W2321227665 @default.
• W2014378729 cites W4247106558 @default.
• W2014378729 doi "https://doi.org/10.1359/jbmr.1998.13.5.786" @default.
• W2014378729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9610742" @default.
• W2014378729 hasPublicationYear "1998" @default.
• W2014378729 type Work @default.
• W2014378729 sameAs 2014378729 @default.
• W2014378729 citedByCount "24" @default.
• W2014378729 countsByYear W20143787292012 @default.
• W2014378729 countsByYear W20143787292017 @default.
• W2014378729 countsByYear W20143787292019 @default.
• W2014378729 countsByYear W20143787292020 @default.
• W2014378729 crossrefType "journal-article" @default.
• W2014378729 hasAuthorship W2014378729A5026523592 @default.
• W2014378729 hasAuthorship W2014378729A5049886691 @default.
• W2014378729 hasAuthorship W2014378729A5057928016 @default.
• W2014378729 hasAuthorship W2014378729A5072809437 @default.
• W2014378729 hasBestOaLocation W20143787291 @default.
• W2014378729 hasConcept C126322002 @default.
• W2014378729 hasConcept C133605539 @default.
• W2014378729 hasConcept C134018914 @default.
• W2014378729 hasConcept C146562846 @default.
• W2014378729 hasConcept C185592680 @default.
• W2014378729 hasConcept C202751555 @default.
• W2014378729 hasConcept C2776541429 @default.
• W2014378729 hasConcept C2777251235 @default.
• W2014378729 hasConcept C2777371288 @default.
• W2014378729 hasConcept C2778260815 @default.
• W2014378729 hasConcept C2778690821 @default.
• W2014378729 hasConcept C2779809032 @default.
• W2014378729 hasConcept C55493867 @default.
• W2014378729 hasConcept C673006 @default.
• W2014378729 hasConcept C71924100 @default.
• W2014378729 hasConcept C74172505 @default.
• W2014378729 hasConceptScore W2014378729C126322002 @default.
• W2014378729 hasConceptScore W2014378729C133605539 @default.
• W2014378729 hasConceptScore W2014378729C134018914 @default.
• W2014378729 hasConceptScore W2014378729C146562846 @default.
• W2014378729 hasConceptScore W2014378729C185592680 @default.
• W2014378729 hasConceptScore W2014378729C202751555 @default.
• W2014378729 hasConceptScore W2014378729C2776541429 @default.
• W2014378729 hasConceptScore W2014378729C2777251235 @default.
• W2014378729 hasConceptScore W2014378729C2777371288 @default.
• W2014378729 hasConceptScore W2014378729C2778260815 @default.
• W2014378729 hasConceptScore W2014378729C2778690821 @default.
• W2014378729 hasConceptScore W2014378729C2779809032 @default.
• W2014378729 hasConceptScore W2014378729C55493867 @default.
• W2014378729 hasConceptScore W2014378729C673006 @default.
• W2014378729 hasConceptScore W2014378729C71924100 @default.
• W2014378729 hasConceptScore W2014378729C74172505 @default.
• W2014378729 hasIssue "5" @default.

• next