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- W2014378733 abstract "γ-glutamyl transpeptidase (γ-GT) deficiency in GGTenu1 mice is associated with glutathionemia, glutathionuria, growth retardation, infertility, lethargy, cataracts, and shortened life span. Total liver glutathione (GSH) content is significantly reduced in γ-GT-deficient mice due to chronic excessive GSH loss. Oral supplementation of GGTenu1 mice with L-2-oxothiazolidine-4-carboxylate (OTZ), a cysteine prodrug, led to partial restoration of liver GSH content. The growth, physical appearance, and behavior of γ-GT-deficient mice were substantially improved following OTZ supplementation. Tissue GSH deficiency is the proximate cause of the phenotypic abnormalities associated with murine γ-GT deficiency." @default.
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- W2014378733 date "2003-06-01" @default.
- W2014378733 modified "2023-09-25" @default.
- W2014378733 title "L-2-oxothiazolidine-4-carboxylate supplementation in murine γ-GT deficiency" @default.
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- W2014378733 doi "https://doi.org/10.1016/s0891-5849(03)00181-3" @default.
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