Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014383571> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2014383571 endingPage "167" @default.
- W2014383571 startingPage "161" @default.
- W2014383571 abstract "An integrated metabonomics study using high-resolution 1H nuclear magnetic resonance (NMR) spectroscopy has been applied to investigate the biochemical composition of urine, serum, liver tissue aqueous extracts (acetonitrile/water) and liver tissue lipidic extracts (chloroform/methanol) obtained from control and Bay41-4109 treated rats (10, 50, 400 mg·kg−1·d−1 for 5 days, i.g.). Principal components analysis was used to visualize similarities and differences in biochemical profiles. The results showed the effects induced by Bay41-4109 at 400 mg·kg−1·d−1 are different from those induced at 10, 50 mg·kg−1·d−1. The biochemical profiles of 400 mg·kg−1·d−1 group might reflect the hepatotoxicity of Bay41-4109 more exactly. The elevation in the level of 3-HB, lactate, 2-hydroxy-acetol and d-glucose was found in the urine, and the levels of VLDL/LDL(CH2)n, VLDL/LDL-CH3, 2-oxo-3-methyl-n-valerate, 3-HB, lactate, acetate, taurine, 2-hydroxy-isovalerate in serum were increased significantly in 400 mg·kg−1·d−1 group. The predominant changes identified in liver tissue aqueous extracts included an increase in the signal intensities of lactate, 3-amino-isovalerate, pyruvate, choline, trimethylamine-N-oxide (TMAO) and a reduction in the intensities of taurine, hippurate and d-glucose. In liver tissue chloroform/methanol extracts, there was a remarkably increase in many of the lipid signals including the triglyceride terminal methyl, methylene groups, and CH2CO, N+(CH3)3, CH2OPO2, CH2OCOR. These observations all provide evidence that fatty acid metabolism disorder and mitochondrial inability might contribute to the hepatotoxicity of Bay41-4109. The application of 1H NMR spectroscopy to an array of biological samples comprising urine, serum and liver tissue extracts yields new insight into the hepatotoxicity of xenobiotics." @default.
- W2014383571 created "2016-06-24" @default.
- W2014383571 creator A5000001452 @default.
- W2014383571 creator A5007288468 @default.
- W2014383571 creator A5023224950 @default.
- W2014383571 creator A5026960270 @default.
- W2014383571 creator A5036207701 @default.
- W2014383571 creator A5042723278 @default.
- W2014383571 date "2007-09-01" @default.
- W2014383571 modified "2023-10-08" @default.
- W2014383571 title "NMR-spectroscopy-based metabonomic approach to the analysis of Bay41-4109, a novel anti-HBV compound, induced hepatotoxicity in rats" @default.
- W2014383571 cites W1797956629 @default.
- W2014383571 cites W1968813633 @default.
- W2014383571 cites W1978619016 @default.
- W2014383571 cites W1995051707 @default.
- W2014383571 cites W2031357416 @default.
- W2014383571 cites W2038948474 @default.
- W2014383571 cites W2054530200 @default.
- W2014383571 cites W2067483513 @default.
- W2014383571 cites W2077249034 @default.
- W2014383571 cites W2079676258 @default.
- W2014383571 cites W2084608143 @default.
- W2014383571 cites W2085851020 @default.
- W2014383571 cites W2089534183 @default.
- W2014383571 cites W2090696847 @default.
- W2014383571 cites W2092193247 @default.
- W2014383571 cites W2104688517 @default.
- W2014383571 cites W2118461556 @default.
- W2014383571 cites W2136744556 @default.
- W2014383571 doi "https://doi.org/10.1016/j.toxlet.2007.07.010" @default.
- W2014383571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17826925" @default.
- W2014383571 hasPublicationYear "2007" @default.
- W2014383571 type Work @default.
- W2014383571 sameAs 2014383571 @default.
- W2014383571 citedByCount "46" @default.
- W2014383571 countsByYear W20143835712012 @default.
- W2014383571 countsByYear W20143835712013 @default.
- W2014383571 countsByYear W20143835712014 @default.
- W2014383571 countsByYear W20143835712015 @default.
- W2014383571 countsByYear W20143835712016 @default.
- W2014383571 countsByYear W20143835712017 @default.
- W2014383571 countsByYear W20143835712018 @default.
- W2014383571 countsByYear W20143835712019 @default.
- W2014383571 countsByYear W20143835712020 @default.
- W2014383571 countsByYear W20143835712021 @default.
- W2014383571 countsByYear W20143835712022 @default.
- W2014383571 crossrefType "journal-article" @default.
- W2014383571 hasAuthorship W2014383571A5000001452 @default.
- W2014383571 hasAuthorship W2014383571A5007288468 @default.
- W2014383571 hasAuthorship W2014383571A5023224950 @default.
- W2014383571 hasAuthorship W2014383571A5026960270 @default.
- W2014383571 hasAuthorship W2014383571A5036207701 @default.
- W2014383571 hasAuthorship W2014383571A5042723278 @default.
- W2014383571 hasConcept C100544194 @default.
- W2014383571 hasConcept C185592680 @default.
- W2014383571 hasConcept C2776979534 @default.
- W2014383571 hasConcept C2779701627 @default.
- W2014383571 hasConcept C2780962039 @default.
- W2014383571 hasConcept C2781144210 @default.
- W2014383571 hasConcept C43617362 @default.
- W2014383571 hasConcept C515207424 @default.
- W2014383571 hasConcept C55493867 @default.
- W2014383571 hasConceptScore W2014383571C100544194 @default.
- W2014383571 hasConceptScore W2014383571C185592680 @default.
- W2014383571 hasConceptScore W2014383571C2776979534 @default.
- W2014383571 hasConceptScore W2014383571C2779701627 @default.
- W2014383571 hasConceptScore W2014383571C2780962039 @default.
- W2014383571 hasConceptScore W2014383571C2781144210 @default.
- W2014383571 hasConceptScore W2014383571C43617362 @default.
- W2014383571 hasConceptScore W2014383571C515207424 @default.
- W2014383571 hasConceptScore W2014383571C55493867 @default.
- W2014383571 hasIssue "3" @default.
- W2014383571 hasLocation W20143835711 @default.
- W2014383571 hasLocation W20143835712 @default.
- W2014383571 hasOpenAccess W2014383571 @default.
- W2014383571 hasPrimaryLocation W20143835711 @default.
- W2014383571 hasRelatedWork W1497541749 @default.
- W2014383571 hasRelatedWork W1647262519 @default.
- W2014383571 hasRelatedWork W1996190273 @default.
- W2014383571 hasRelatedWork W2044992314 @default.
- W2014383571 hasRelatedWork W2065541362 @default.
- W2014383571 hasRelatedWork W2319553557 @default.
- W2014383571 hasRelatedWork W2380633980 @default.
- W2014383571 hasRelatedWork W2429265210 @default.
- W2014383571 hasRelatedWork W4230312442 @default.
- W2014383571 hasRelatedWork W6228773 @default.
- W2014383571 hasVolume "173" @default.
- W2014383571 isParatext "false" @default.
- W2014383571 isRetracted "false" @default.
- W2014383571 magId "2014383571" @default.
- W2014383571 workType "article" @default.