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- W2014386327 abstract "Human T and natural-killer (NK) cells, that are thought to be the major cytotoxic effector-cell populations in the defence against neoplastic cells, were isolated from blood and decidua in order to analyze their expression of carcinoembronic-antigen-(CEA)-family-member proteins. Biliary glycoprotein (BGP, CD66a) was the only member of the carcinoembryonic antigen family detected. While freshly isolated T-cells expressed low amounts of BGP, freshly isolated NK cells were negative. After in vitro stimulation for 3 days,T cells up-regulated their BGP expression and a sub-group of NK cells (CD16− CD56+), known to predominate in decidua, revealed de novo expression of BGP. In contrast, stimulated CD16+ CD56+ NK cells, which occur exclusively in the blood, remained negative. The expression of BGP could be shown on the protein level by using a panel of 12 well-defined MAbs and on the transcription level in rt-PCR and subsequent oligonucleotide hybridization. Interestingly, rIL-2-stimulated T cells expressed 3-fold higher levels of BGP compared with those seen after stimulation with phytohemaglutinine (PHA). PHA, on the other hand, induced a higher expression of HLA-DR, an activation marker of T cells. The differential regulation implies a distinct function of BGP and HLA-DR. © 1996 Wiley-Liss, Inc." @default.
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- W2014386327 date "1996-03-15" @default.
- W2014386327 modified "2023-09-27" @default.
- W2014386327 title "Biliary glycoprotein (BGP) expression on T cells and on a natural-killer-cell sub-population" @default.
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- W2014386327 doi "https://doi.org/10.1002/(sici)1097-0215(19960315)65:6<740::aid-ijc5>3.0.co;2-z" @default.
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