Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014387465> ?p ?o ?g. }
- W2014387465 endingPage "192" @default.
- W2014387465 startingPage "185" @default.
- W2014387465 abstract "Indolicidin (ILPWKWPWWPWRR-NH2) has received attention due to its unique primary structure and biological activities. In this study, amide bonds at various positions in indolicidin were replaced with the reduced amide bonds ψ[CH2NH] and the effect of the secondary structure on the biological activity was investigated. The circular dichroism spectra revealed that the rigidity and hydrogen bond of the amide bond between Trp8 and Trp9 were important for stabilizing the turn structure of indolicidin. A structure–activity study revealed that the turn structure of indolicidin was not required for antimicrobial activity and leakage activity for LUVs with a negatively charged surface. The pseudopeptide containing two reduced amide bonds showed less hemolytic activity as well as improved stability without a decrease in its antimicrobial activity. These results will provide valuable information for designing indolicidin analogs with greater bacterial selectivity and increased stability and for elucidating the role of the secondary structure of membrane-active peptides for antimicrobial and hemolytic activities." @default.
- W2014387465 created "2016-06-24" @default.
- W2014387465 creator A5003377342 @default.
- W2014387465 creator A5003962263 @default.
- W2014387465 creator A5050206931 @default.
- W2014387465 creator A5062100767 @default.
- W2014387465 creator A5088971868 @default.
- W2014387465 date "2009-02-01" @default.
- W2014387465 modified "2023-10-15" @default.
- W2014387465 title "Indolicidin-derived antimicrobial peptide analogs with greater bacterial selectivity and requirements for antibacterial and hemolytic activities" @default.
- W2014387465 cites W1525385499 @default.
- W2014387465 cites W1556677948 @default.
- W2014387465 cites W1812202403 @default.
- W2014387465 cites W1847489898 @default.
- W2014387465 cites W1964937304 @default.
- W2014387465 cites W1983792266 @default.
- W2014387465 cites W1986516374 @default.
- W2014387465 cites W1987348853 @default.
- W2014387465 cites W1989202079 @default.
- W2014387465 cites W1989505230 @default.
- W2014387465 cites W2009756829 @default.
- W2014387465 cites W2012180876 @default.
- W2014387465 cites W2021017618 @default.
- W2014387465 cites W2037455416 @default.
- W2014387465 cites W2037472715 @default.
- W2014387465 cites W2038512626 @default.
- W2014387465 cites W2042290438 @default.
- W2014387465 cites W2046783706 @default.
- W2014387465 cites W2052148977 @default.
- W2014387465 cites W2053404249 @default.
- W2014387465 cites W2054137507 @default.
- W2014387465 cites W2054602599 @default.
- W2014387465 cites W2056013343 @default.
- W2014387465 cites W2056135942 @default.
- W2014387465 cites W2068001811 @default.
- W2014387465 cites W2068174333 @default.
- W2014387465 cites W2076718110 @default.
- W2014387465 cites W2079809606 @default.
- W2014387465 cites W2081090090 @default.
- W2014387465 cites W2082917080 @default.
- W2014387465 cites W2095256077 @default.
- W2014387465 cites W2101158888 @default.
- W2014387465 cites W2108246317 @default.
- W2014387465 cites W2114283460 @default.
- W2014387465 cites W2114381140 @default.
- W2014387465 cites W2115050101 @default.
- W2014387465 cites W2121533469 @default.
- W2014387465 cites W2154904449 @default.
- W2014387465 cites W2164487093 @default.
- W2014387465 cites W2165500804 @default.
- W2014387465 cites W2951142179 @default.
- W2014387465 cites W4250801337 @default.
- W2014387465 cites W4251600401 @default.
- W2014387465 doi "https://doi.org/10.1016/j.bbapap.2008.10.009" @default.
- W2014387465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19038369" @default.
- W2014387465 hasPublicationYear "2009" @default.
- W2014387465 type Work @default.
- W2014387465 sameAs 2014387465 @default.
- W2014387465 citedByCount "17" @default.
- W2014387465 countsByYear W20143874652013 @default.
- W2014387465 countsByYear W20143874652016 @default.
- W2014387465 countsByYear W20143874652017 @default.
- W2014387465 countsByYear W20143874652019 @default.
- W2014387465 countsByYear W20143874652020 @default.
- W2014387465 countsByYear W20143874652021 @default.
- W2014387465 countsByYear W20143874652023 @default.
- W2014387465 crossrefType "journal-article" @default.
- W2014387465 hasAuthorship W2014387465A5003377342 @default.
- W2014387465 hasAuthorship W2014387465A5003962263 @default.
- W2014387465 hasAuthorship W2014387465A5050206931 @default.
- W2014387465 hasAuthorship W2014387465A5062100767 @default.
- W2014387465 hasAuthorship W2014387465A5088971868 @default.
- W2014387465 hasConcept C112887158 @default.
- W2014387465 hasConcept C118792377 @default.
- W2014387465 hasConcept C133571119 @default.
- W2014387465 hasConcept C161790260 @default.
- W2014387465 hasConcept C178790620 @default.
- W2014387465 hasConcept C185592680 @default.
- W2014387465 hasConcept C21951064 @default.
- W2014387465 hasConcept C2778439535 @default.
- W2014387465 hasConcept C2779281246 @default.
- W2014387465 hasConcept C2780104969 @default.
- W2014387465 hasConcept C31684184 @default.
- W2014387465 hasConcept C32909587 @default.
- W2014387465 hasConcept C4937899 @default.
- W2014387465 hasConcept C523546767 @default.
- W2014387465 hasConcept C54355233 @default.
- W2014387465 hasConcept C55493867 @default.
- W2014387465 hasConcept C62614982 @default.
- W2014387465 hasConcept C71240020 @default.
- W2014387465 hasConcept C86803240 @default.
- W2014387465 hasConceptScore W2014387465C112887158 @default.
- W2014387465 hasConceptScore W2014387465C118792377 @default.
- W2014387465 hasConceptScore W2014387465C133571119 @default.
- W2014387465 hasConceptScore W2014387465C161790260 @default.
- W2014387465 hasConceptScore W2014387465C178790620 @default.
- W2014387465 hasConceptScore W2014387465C185592680 @default.
- W2014387465 hasConceptScore W2014387465C21951064 @default.