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- W2014389247 abstract "Although relationships between networks of different scales have been observed in macroscopic brain studies, relationships between structures of different scales in networks of neurons are unknown. To address this, we recorded from up to 500 neurons simultaneously from slice cultures of rodent somatosensory cortex. We then measured directed effective networks with transfer entropy, previously validated in simulated cortical networks. These effective networks enabled us to evaluate distinctive nonrandom structures of connectivity at 2 different scales. We have 4 main findings. First, at the scale of 3-6 neurons (clusters), we found that high numbers of connections occurred significantly more often than expected by chance. Second, the distribution of the number of connections per neuron (degree distribution) had a long tail, indicating that the network contained distinctively high-degree neurons, or hubs. Third, at the scale of tens to hundreds of neurons, we typically found 2-3 significantly large communities. Finally, we demonstrated that communities were relatively more robust than clusters against shuffling of connections. We conclude the microconnectome of the cortex has specific organization at different scales, as revealed by differences in robustness. We suggest that this information will help us to understand how the microconnectome is robust against damage." @default.
- W2014389247 created "2016-06-24" @default.
- W2014389247 creator A5040666664 @default.
- W2014389247 creator A5053081324 @default.
- W2014389247 date "2014-10-21" @default.
- W2014389247 modified "2023-09-29" @default.
- W2014389247 title "Functional Clusters, Hubs, and Communities in the Cortical Microconnectome" @default.
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