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• W2014391569 abstract "Extracellular dopamine (DA) levels in the steady state were not detected in the hippocampus of rats where sparse dopaminergic innervations were demonstrated. However, following L-DOPA (100 mg/kg i.p.) administration, extracellular DA was detected. Although tetrodotoxin (TTX, 1 microM) failed to prevent this phenomenon, the striatal DA peak disappeared with the addition of TTX (5 microM) into the perfusate and reappeared following L-DOPA (100 mg/kg i.p.) administration. These findings suggest that DA synthesis from L-DOPA, administered exogenously, is independent of the existence of dopaminergic neurons and that outflow of newly synthesized DA into the extracellular space is not coupled to neuronal activity." @default.
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• W2014391569 date "1993-05-01" @default.
• W2014391569 modified "2023-10-16" @default.
• W2014391569 title "Dopamine formation from L-DOPA administered exogenously is independent of dopaminergic neuronal activity: studies with in vivo microdialysis" @default.
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• W2014391569 doi "https://doi.org/10.1016/0006-8993(93)91787-s" @default.
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