Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014394142> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W2014394142 endingPage "810" @default.
- W2014394142 startingPage "793" @default.
- W2014394142 abstract "Abstract Because polyamines are critically involved in the proliferation of neoplastic tissues, enzymes in their synthetic pathway present rational targets for the development of anticancer agents. AdoDATO is a potent and specific transition-state analog inhibitor of the key polyamine biosynthetic enzyme, spermidine synthase, and in in vitro systems leads to the inhibition of cell proliferation via polyamine depletion. In order to evaluate the in vivo effectiveness of AdoDATO, the synthesis of this inhibitor has been scaled up using the reported procedure. This paper describes the development of a preparative HPLC procedure for the purification of AdoDATO by paired-ion chromatography. This methodology could also be used to purify other strongly basic compounds that contain hydrophobic regions." @default.
- W2014394142 created "2016-06-24" @default.
- W2014394142 creator A5037290892 @default.
- W2014394142 creator A5038615438 @default.
- W2014394142 creator A5040657216 @default.
- W2014394142 creator A5085439836 @default.
- W2014394142 date "1988-03-01" @default.
- W2014394142 modified "2023-09-27" @default.
- W2014394142 title "Purification of S-Adenosyl-1,8, diamino-3-thiooctane (AdoDATO) by Preparative High Performance Liquid Chromatography" @default.
- W2014394142 cites W1965440713 @default.
- W2014394142 cites W2030901966 @default.
- W2014394142 cites W2055275842 @default.
- W2014394142 cites W2074868165 @default.
- W2014394142 cites W2088056855 @default.
- W2014394142 cites W2170687595 @default.
- W2014394142 cites W2273435658 @default.
- W2014394142 doi "https://doi.org/10.1080/01483918808068345" @default.
- W2014394142 hasPublicationYear "1988" @default.
- W2014394142 type Work @default.
- W2014394142 sameAs 2014394142 @default.
- W2014394142 citedByCount "0" @default.
- W2014394142 crossrefType "journal-article" @default.
- W2014394142 hasAuthorship W2014394142A5037290892 @default.
- W2014394142 hasAuthorship W2014394142A5038615438 @default.
- W2014394142 hasAuthorship W2014394142A5040657216 @default.
- W2014394142 hasAuthorship W2014394142A5085439836 @default.
- W2014394142 hasConcept C179998833 @default.
- W2014394142 hasConcept C185592680 @default.
- W2014394142 hasConcept C43617362 @default.
- W2014394142 hasConceptScore W2014394142C179998833 @default.
- W2014394142 hasConceptScore W2014394142C185592680 @default.
- W2014394142 hasConceptScore W2014394142C43617362 @default.
- W2014394142 hasIssue "4" @default.
- W2014394142 hasLocation W20143941421 @default.
- W2014394142 hasOpenAccess W2014394142 @default.
- W2014394142 hasPrimaryLocation W20143941421 @default.
- W2014394142 hasRelatedWork W2046024352 @default.
- W2014394142 hasRelatedWork W2095306786 @default.
- W2014394142 hasRelatedWork W2114353500 @default.
- W2014394142 hasRelatedWork W2145213465 @default.
- W2014394142 hasRelatedWork W2189200885 @default.
- W2014394142 hasRelatedWork W2352674505 @default.
- W2014394142 hasRelatedWork W2360903818 @default.
- W2014394142 hasRelatedWork W2405302437 @default.
- W2014394142 hasRelatedWork W2417209194 @default.
- W2014394142 hasRelatedWork W3177929758 @default.
- W2014394142 hasVolume "11" @default.
- W2014394142 isParatext "false" @default.
- W2014394142 isRetracted "false" @default.
- W2014394142 magId "2014394142" @default.
- W2014394142 workType "article" @default.