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- W2014394515 abstract "Prepulse inhibition of startle is a model of sensorimotor gating, which is disrupted in alcoholism, as well as mental illnesses such as schizophrenia. The fawn-hooded (FH) rat strain has been used as an animal model of alcoholism. FH rats showed significantly lower startle amplitude than Wistar–Kyoto (WKY) rats and Sprague–Dawley (SD) rats. Increasing doses of the 5-HT1A receptor agonist 8-OH-DPAT caused disruption of PPI, with the effect being significantly greater in FH rats compared to WKY rats. In all strains, treatment with 0.5 mg/kg of 8-OH-DPAT significantly reduced PPI. In contrast, 0.1 mg/kg of 8-OH-DPAT caused disruption only in the FH strain. Treatment with amphetamine, apomorphine and MK-801 also significantly reduced PPI, however, there was no difference between the strains. This study shows increased sensitivity of FH rats to the disruption of PPI caused by 5-HT1A receptor stimulation, suggesting a link between 5-HT1A receptors, sensorimotor gating and aspects of the FH rat phenotype." @default.
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- W2014394515 date "2004-10-01" @default.
- W2014394515 modified "2023-10-11" @default.
- W2014394515 title "Prepulse inhibition in fawn-hooded rats: increased sensitivity to 5-HT1A receptor stimulation" @default.
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- W2014394515 doi "https://doi.org/10.1016/j.euroneuro.2003.10.008" @default.
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