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- W2014395746 abstract "1.1. Cairomycin B (CB) inhibits nucleic acid and protein synthesis in cells of Staphylococcus aureus.2.2. The antibiotic elevated the Tm of DNA while that of RNA was lowered.3.3. DNA dependent RNA polymerase was inhibited by the antibiotic.4.4. Sedimentation properties of DNA & RNA with CB showed an increase in their S values. Sedimentation analysis for mixtures left after Tm determination showed the same pattern as the unheated mixture containing DNA whereas that containing RNA revealed fewer fractions.5.5. The [3H]CB bound with [14C]DNA and with ribosomal RNA; mainly the 50 S subunits and the 70 S as well.6.6. CB was found to interfere with polypeptide chain elongation but not with the initiation step.7.7. Miscoding induced by CB during polypeptide synthesis through misreading of U as A in 5-terminal of UUU triplet was also demonstrated." @default.
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- W2014395746 date "1979-01-01" @default.
- W2014395746 modified "2023-09-26" @default.
- W2014395746 title "The mechanism of action of cairomycin B" @default.
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- W2014395746 doi "https://doi.org/10.1016/0020-711x(79)90007-7" @default.
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