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- W2014397746 abstract "Background Cadmium exposure may cause renal damage, first shown as a tubular damage. Different methods are used to assess the degree of the tubular damage, most often the amounts of different small proteins in the urine, which are usually absorbed in the tubuli (e.g. protein-HC and B2-microglobulin) are measured. A different approach to measure the degree of tubular damage is to measure NAG, an enzyme, which is found in tubular cells, in urine. There are two different types of iso-enzymes NAG-A and NAG-B. Earlier studies have most often measured the total-NAG (NAG-A + NAG-B). The present study aimed to study the dose-effect relationship between the different iso-enzymes of NAG and cadmium in a population exposed to relatively low levels of cadmium. Methods 1021 individuals occupationally or environmentally exposed to cadmium were included in the study. Cadmium in urine (U-Cd) was used as dose estimate and NAG-A and NAG-B (u/mmol creatinine) were used to assess tubular damage. Results. A positive, statistically significant, linear relation was found between cadmium in urine and NAG-A, after adjustment for age and gender, but not for NAG-B. The table shows the regression coefficients for the independent variables age and U-Cd, with NAG-A and NAG-B as the dependent variables. When the analyses were restricted to environmentally exposed persons, the results remained essentially the same." @default.
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- W2014397746 date "2003-09-01" @default.
- W2014397746 modified "2023-10-17" @default.
- W2014397746 title "NAG AS A MARKER OF CADMIUM INDUCED TUBULAR RENAL DAMAGE" @default.
- W2014397746 doi "https://doi.org/10.1097/00001648-200309001-00136" @default.
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