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• W2014405787 endingPage "288" @default.
• W2014405787 startingPage "280" @default.
• W2014405787 abstract "Basal differences in the brain may account for why some individuals are more vulnerable to stress than others. Although trait anxiety behavior varies greatly in human populations, most animal models of anxiety disorders tend to focus on the development of anxiety after a stressful experience. In this study, adult male Sprague-Dawley and Lewis rats were grouped according to baseline anxiety-like behavior in the open field, measured by time spent and distance traveled in the center. Individuals that fell one standard deviation above and below the mean, approximately the top and bottom 15%, were selected for the Low and High Anxiety groups. Pyramidal neurons from layer II/III of the prelimbic region of the medial prefrontal cortex were iontophoretically loaded with Lucifer yellow dye and reconstructed. In both strains, animals in the High Anxiety group had smaller apical dendrites than those in the Low Anxiety group. No difference was found in basal dendrites. Sholl analysis revealed a strain difference in the distribution of dendritic material between anxiety groups. These results illustrate significant variability in dendritic morphology in the prefrontal cortex of healthy adult male rats prior to experimental manipulation that correlates with baseline levels of anxiety-like behavior." @default.
• W2014405787 created "2016-06-24" @default.
• W2014405787 creator A5035103174 @default.
• W2014405787 creator A5045886993 @default.
• W2014405787 creator A5073929646 @default.
• W2014405787 date "2012-04-01" @default.
• W2014405787 modified "2023-09-23" @default.
• W2014405787 title "Basal anxiety-like behavior predicts differences in dendritic morphology in the medial prefrontal cortex in two strains of rats" @default.
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• W2014405787 doi "https://doi.org/10.1016/j.bbr.2012.01.029" @default.
• W2014405787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22285422" @default.

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