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- W2014406919 abstract "Abstract Auditory function can be affected by many factors, including environment and experience. In this study, we investigated whether early auditory experience mediates the regulation of the composition/ratio changes of the N‐methyl‐D‐aspartic acid (NMDA) receptor subunits during development of the rat auditory cortex. We found that early sound exposure can increase expression of the NMDA receptor subunits and increase the composition/ratios of NMDA receptor subunits during the postnatal critical period. D‐2‐amino‐5‐phosphonovaleric acid (D‐APV) could block and reverse the auditory experience‐mediated changes, and there were marked reductions in expression levels and the composition/ratios of NMDA receptor subunits. These results indicate that the experience‐dependent plasticity of the auditory cortex in the critical period during postnatal development has a marked influence on NMDA receptor expression in the rat and that changes in NMDA receptor subunit composition/ratios might mediate the early auditory experience‐dependent plasticity crucial to auditory function. © 2008 Wiley‐Liss, Inc." @default.
- W2014406919 created "2016-06-24" @default.
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- W2014406919 date "2008-11-21" @default.
- W2014406919 modified "2023-10-16" @default.
- W2014406919 title "Early auditory experience-induced composition/ratio changes of N-methyl-D-aspartate receptor subunit expression and effects of D-2-amino-5-phosphonovaleric acid chronic blockade in rat auditory cortex" @default.
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- W2014406919 doi "https://doi.org/10.1002/jnr.21936" @default.
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