Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014408077> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2014408077 endingPage "452" @default.
- W2014408077 startingPage "439" @default.
- W2014408077 abstract "beta-(3,4-epoxycyclohexyl)ethyltrimethoxysilane (ECEMS, CAS No. 3388-04-3) is mutagenic in vitro and weakly carcinogenic in mice after dermal application. Timed pregnant Fischer 344 rats and New Zealand white rabbits were dosed with ECEMS in corn oil by gavage on gestational days (gd) 6 through 15 at doses of 0.0, 0.25, 1.0, or 2.5 ml ECEMS/kg for rats and 0.0, 0.05, 0.25, or 0.75 ml ECEMS/kg for rabbits. At termination on gd 21 (rats) or gd 29 (rabbits), live fetuses were examined for external, visceral, and skeletal alterations. In rats, maternal toxicity was observed at 1.0 and 2.5 ml/kg, as evidenced by reduced weight gain and food consumption during treatment, clinical signs of toxicity, reduced body weight on gd 21 (corrected for gravid uterine weight), and increased relative liver weight. There were no significant differences among groups on pre- or postimplantation loss, fetal body weight/litter, or on the incidence of malformations. Minimal fetal toxicity, dilated lateral cerebral ventricles and reduced ossification in the forelimbs, was observed at 2.5 ml/kg. In rabbits, maternal mortality (2/20 does) and slightly (but statistically significantly) elevated maternal relative kidney weight were observed at 0.75 ml/kg. Clinical signs of toxicity were observed at 0.25 and 0.75 ml/kg. Pre- and postimplantation loss, fetal body weight/litter, and the incidence of malformations were all unaffected by treatment. Minimal fetal toxicity, extra (13th) ribs and reduced ossification in lumbar arch 4, was observed at 0.75 ml/kg ECEMS. Therefore, administration of ECEMS during organogenesis in rats and rabbits produced maternal toxicity at 1.0 and 2.5 ml/kg in rats and at 0.25 and 0.75 ml/kg in rabbits. Minimal fetal toxicity was observed at 2.5 ml/kg in rats and at 0.75 ml/kg in rabbits. No embryotoxicity or teratogenicity was observed in either species at any dosage. The no observable effect level (NOEL) for maternal toxicity was 0.25 ml/kg for rats and 0.05 ml/kg for rabbits; the NOEL for developmental toxicity was 1.0 ml/kg for rats and 0.25 ml/kg for rabbits." @default.
- W2014408077 created "2016-06-24" @default.
- W2014408077 creator A5021073623 @default.
- W2014408077 date "1988-04-01" @default.
- W2014408077 modified "2023-09-25" @default.
- W2014408077 title "Evaluation of the developmental toxicity of ?-(3,4-epoxycyclohexyl)ethyltrimethoxysilane in Fischer 344 rats and New Zealand white rabbits" @default.
- W2014408077 cites W1775964807 @default.
- W2014408077 cites W1987331207 @default.
- W2014408077 cites W2018521898 @default.
- W2014408077 cites W2080785373 @default.
- W2014408077 cites W2093679348 @default.
- W2014408077 cites W2142580290 @default.
- W2014408077 cites W2199235098 @default.
- W2014408077 cites W2332205625 @default.
- W2014408077 cites W2408218023 @default.
- W2014408077 doi "https://doi.org/10.1016/0272-0590(88)90290-4" @default.
- W2014408077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3371583" @default.
- W2014408077 hasPublicationYear "1988" @default.
- W2014408077 type Work @default.
- W2014408077 sameAs 2014408077 @default.
- W2014408077 citedByCount "2" @default.
- W2014408077 countsByYear W20144080772018 @default.
- W2014408077 crossrefType "journal-article" @default.
- W2014408077 hasAuthorship W2014408077A5021073623 @default.
- W2014408077 hasConcept C105702510 @default.
- W2014408077 hasConcept C126322002 @default.
- W2014408077 hasConcept C134018914 @default.
- W2014408077 hasConcept C147583825 @default.
- W2014408077 hasConcept C172680121 @default.
- W2014408077 hasConcept C179335377 @default.
- W2014408077 hasConcept C2778206080 @default.
- W2014408077 hasConcept C2778842504 @default.
- W2014408077 hasConcept C2779234561 @default.
- W2014408077 hasConcept C2779429622 @default.
- W2014408077 hasConcept C29730261 @default.
- W2014408077 hasConcept C54355233 @default.
- W2014408077 hasConcept C65290608 @default.
- W2014408077 hasConcept C6557445 @default.
- W2014408077 hasConcept C71924100 @default.
- W2014408077 hasConcept C86803240 @default.
- W2014408077 hasConceptScore W2014408077C105702510 @default.
- W2014408077 hasConceptScore W2014408077C126322002 @default.
- W2014408077 hasConceptScore W2014408077C134018914 @default.
- W2014408077 hasConceptScore W2014408077C147583825 @default.
- W2014408077 hasConceptScore W2014408077C172680121 @default.
- W2014408077 hasConceptScore W2014408077C179335377 @default.
- W2014408077 hasConceptScore W2014408077C2778206080 @default.
- W2014408077 hasConceptScore W2014408077C2778842504 @default.
- W2014408077 hasConceptScore W2014408077C2779234561 @default.
- W2014408077 hasConceptScore W2014408077C2779429622 @default.
- W2014408077 hasConceptScore W2014408077C29730261 @default.
- W2014408077 hasConceptScore W2014408077C54355233 @default.
- W2014408077 hasConceptScore W2014408077C65290608 @default.
- W2014408077 hasConceptScore W2014408077C6557445 @default.
- W2014408077 hasConceptScore W2014408077C71924100 @default.
- W2014408077 hasConceptScore W2014408077C86803240 @default.
- W2014408077 hasIssue "3" @default.
- W2014408077 hasLocation W20144080771 @default.
- W2014408077 hasLocation W20144080772 @default.
- W2014408077 hasOpenAccess W2014408077 @default.
- W2014408077 hasPrimaryLocation W20144080771 @default.
- W2014408077 hasRelatedWork W1563993066 @default.
- W2014408077 hasRelatedWork W1990273725 @default.
- W2014408077 hasRelatedWork W1992174590 @default.
- W2014408077 hasRelatedWork W2014408077 @default.
- W2014408077 hasRelatedWork W2037410971 @default.
- W2014408077 hasRelatedWork W2052560947 @default.
- W2014408077 hasRelatedWork W2070251905 @default.
- W2014408077 hasRelatedWork W2122140399 @default.
- W2014408077 hasRelatedWork W2414790749 @default.
- W2014408077 hasRelatedWork W4251385330 @default.
- W2014408077 hasVolume "10" @default.
- W2014408077 isParatext "false" @default.
- W2014408077 isRetracted "false" @default.
- W2014408077 magId "2014408077" @default.
- W2014408077 workType "article" @default.