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• W2014414360 abstract "A novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, designated epi-cochlioquinone A has been isolated from the fermentation broth of Stachybotrys bisbyi SANK 17777. The molecular formula, physicochemical properties, NMR spectroscopic analysis and X-ray crystallographic analysis revealed that this compound was a stereoisomer of cochlioquinone A, which has been previously reported as a nematocidal agent. It inhibited ACAT activity in an enzyme assay using rat liver microsomes with an IC50 value of 1.7μM. However, it showed about 10-fold less potent inhibitory effect on plasma lecithin cholesterol acyltransferase (LCAT) than on ACAT. In addition, it inhibited in vivo cholesterol absorption in rats by 50% at 75mg/kg." @default.
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• W2014414360 date "1996-01-01" @default.
• W2014414360 modified "2023-10-14" @default.
• W2014414360 title "Epi-cochlioquinone A, a Novel Acyl-CoA: Cholesterol Acyltransferase Inhibitor Produced by Stachybotrys bisbyi." @default.
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• W2014414360 doi "https://doi.org/10.7164/antibiotics.49.409" @default.
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