FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014416235> ?p ?o ?g. }

• W2014416235 endingPage "360" @default.
• W2014416235 startingPage "347" @default.
• W2014416235 abstract "We investigated the effect on neurochemical phenotype of changing the targets innervated by sympathetic preganglionic neurons. In neonatal rats, the adrenal gland was transplanted into the neck, to replace the postganglionic neurons of the superior cervical ganglion. Transplanted adrenal glands survived, and contained noradrenergic and adrenergic chromaffin cells, and adrenal ganglion cells. Retrograde tracing from the transplants showed that they were innervated by preganglionic neurons that would normally have supplied postganglionic neurons of the superior cervical ganglion. The neurochemical phenotypes of preganglionic axons innervating transplanted chromaffin cells were compared with those innervating the normal adrenal medulla or superior cervical ganglion neurons. As in the normal adrenal gland, preganglionic nerve fibres apposing transplanted chromaffin cells were cholinergic. The peptide and calcium-binding protein content of preganglionic fibres was similar in normal and transplanted adrenal glands. In both cases, cholinergic fibres immunoreactive for enkephalin targeted adrenergic chromaffin cells, whilst cholinergic fibres with co-localised calretinin-immunoreactivity innervated noradrenergic chromaffin cells and adrenal ganglion cells. In contrast to the innervation of normal adrenal glands, these axons lacked immunoreactivity to nitric oxide synthase. In a set of control experiments, the superior cervical ganglion was subjected to preganglionic denervation in rat pups the same age as those that received adrenal transplants, and the ganglion was allowed to be re-innervated over the same time course as the adrenal transplants were studied. When the superior cervical ganglion was re-innervated by preganglionic nerve fibres, we observed that all aspects of chemical coding were restored, including cholinergic markers, nitric oxide synthase, enkephalin, calcitonin gene-related peptide and calcium binding proteins in predicted combinations, although the density of nerve fibres was always lower in re-innervated ganglia. These data show that the neurochemical phenotypes expressed by preganglionic neurons re-innervating adrenal chromaffin cells are selective and similar to those seen in the normal adrenal gland. Two explanations are advanced: either that contact of preganglionic axons with novel target cells has induced a switch in their neurochemical phenotypes, or that there has been target-selective reinnervation by pre-existing fibres of appropriate phenotype. Regardless of which of these alternatives is correct, the restoration of normal preganglionic codes to the superior cervical ganglion following denervation supports the idea that the target tissue influences the neurochemistry of innervating preganglionic neurons." @default.
• W2014416235 created "2016-06-24" @default.
• W2014416235 creator A5031535978 @default.
• W2014416235 creator A5034957929 @default.
• W2014416235 creator A5043075846 @default.
• W2014416235 creator A5084495640 @default.
• W2014416235 creator A5084711008 @default.
• W2014416235 date "2003-03-01" @default.
• W2014416235 modified "2023-10-15" @default.
• W2014416235 title "Re-establishment of neurochemical coding of preganglionic neurons innervating transplanted targets" @default.
• W2014416235 cites W1038942438 @default.
• W2014416235 cites W1485241464 @default.
• W2014416235 cites W1489696679 @default.
• W2014416235 cites W1519817111 @default.
• W2014416235 cites W1926979123 @default.
• W2014416235 cites W1965310829 @default.
• W2014416235 cites W1965403117 @default.
• W2014416235 cites W1966794954 @default.
• W2014416235 cites W1971205124 @default.
• W2014416235 cites W1972841407 @default.
• W2014416235 cites W1973094418 @default.
• W2014416235 cites W1974268461 @default.
• W2014416235 cites W1983923023 @default.
• W2014416235 cites W1998153514 @default.
• W2014416235 cites W1999338872 @default.
• W2014416235 cites W1999473847 @default.
• W2014416235 cites W2002866183 @default.
• W2014416235 cites W2005601991 @default.
• W2014416235 cites W2005734269 @default.
• W2014416235 cites W2007804882 @default.
• W2014416235 cites W2009630172 @default.
• W2014416235 cites W2011202256 @default.
• W2014416235 cites W2013547380 @default.
• W2014416235 cites W2016186852 @default.
• W2014416235 cites W2016705120 @default.
• W2014416235 cites W2020708987 @default.
• W2014416235 cites W2021633605 @default.
• W2014416235 cites W2024359680 @default.
• W2014416235 cites W2029217221 @default.
• W2014416235 cites W2030365382 @default.
• W2014416235 cites W2031212154 @default.
• W2014416235 cites W2031753737 @default.
• W2014416235 cites W2032671797 @default.
• W2014416235 cites W2044678258 @default.
• W2014416235 cites W2046237526 @default.
• W2014416235 cites W2050350741 @default.
• W2014416235 cites W2052165076 @default.
• W2014416235 cites W2052203320 @default.
• W2014416235 cites W2055894296 @default.
• W2014416235 cites W2056510780 @default.
• W2014416235 cites W2056967993 @default.
• W2014416235 cites W2058771734 @default.
• W2014416235 cites W2061227729 @default.
• W2014416235 cites W2061762458 @default.
• W2014416235 cites W2062576971 @default.
• W2014416235 cites W2063614313 @default.
• W2014416235 cites W2065157495 @default.
• W2014416235 cites W2068480472 @default.
• W2014416235 cites W2077374252 @default.
• W2014416235 cites W2079373488 @default.
• W2014416235 cites W2082403564 @default.
• W2014416235 cites W2086189627 @default.
• W2014416235 cites W2086466427 @default.
• W2014416235 cites W2087406805 @default.
• W2014416235 cites W2088683988 @default.
• W2014416235 cites W2090346146 @default.
• W2014416235 cites W2092884273 @default.
• W2014416235 cites W2104772064 @default.
• W2014416235 cites W2134022846 @default.
• W2014416235 cites W2154673290 @default.
• W2014416235 cites W2166025435 @default.
• W2014416235 cites W2171782555 @default.
• W2014416235 doi "https://doi.org/10.1016/s0306-4522(02)00828-x" @default.
• W2014416235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12614675" @default.
• W2014416235 hasPublicationYear "2003" @default.
• W2014416235 type Work @default.
• W2014416235 sameAs 2014416235 @default.
• W2014416235 citedByCount "12" @default.
• W2014416235 countsByYear W20144162352014 @default.
• W2014416235 countsByYear W20144162352015 @default.
• W2014416235 countsByYear W20144162352016 @default.
• W2014416235 countsByYear W20144162352018 @default.
• W2014416235 crossrefType "journal-article" @default.
• W2014416235 hasAuthorship W2014416235A5031535978 @default.
• W2014416235 hasAuthorship W2014416235A5034957929 @default.
• W2014416235 hasAuthorship W2014416235A5043075846 @default.
• W2014416235 hasAuthorship W2014416235A5084495640 @default.
• W2014416235 hasAuthorship W2014416235A5084711008 @default.
• W2014416235 hasConcept C105702510 @default.
• W2014416235 hasConcept C126322002 @default.
• W2014416235 hasConcept C134018914 @default.
• W2014416235 hasConcept C204232928 @default.
• W2014416235 hasConcept C22885893 @default.
• W2014416235 hasConcept C25876315 @default.
• W2014416235 hasConcept C2775894120 @default.
• W2014416235 hasConcept C2776805190 @default.
• W2014416235 hasConcept C2777597313 @default.
• W2014416235 hasConcept C2777646271 @default.

• next