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- W201442902 abstract "Hormones have an extremely large impact on seizures and epilepsy. Stress and stress hormones are known to reinforce seizure expression, and gonadal hormones affect the number of seizures and even the seizure type. Moreover, hormonal concentrations change drastically over an individual's lifetime, especially in women. The prevailing view on steroid hormones is that estrogen and corticosteroid hormones are proconvulsant, whereas progesterone is anticonvulsant. The neuroactive steroids may exert some of their effects nongenomically through their action on classical GABA receptors. However, understanding the interaction between the GABA system and hormones in absence epilepsy is complicated by the peculiar pharmacological profile exhibited by absence epilepsy (which is opposite to the profile seen in other types of seizures). Moreover, absences are associated with hyperfunction of the GABAergic inhibitory system. Thus, the relations between hormones that modulate the GABA receptors and absence epilepsy must be given special attention. Outcomes of recent pharmacological studies with progesterone show that acute systemic administration exacerbates absence seizures, that absence seizures are virtually reduced during pregnancy when plasma levels are chronically elevated, and that intrahippocampal administration of progesterone reduces spike-wave discharges. This suggests a complicated relationship between progesterone and absence seizures. How progesterone affects absence seizures is an important, fascinating, and challenging question." @default.
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- W201442902 date "2009-01-01" @default.
- W201442902 modified "2023-09-23" @default.
- W201442902 title "HORMONES AND GENDER | Hormones and Absence Epilepsy" @default.
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- W201442902 doi "https://doi.org/10.1016/b978-012373961-2.00198-3" @default.
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