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• W2014429983 abstract "C/EBPα plays important roles in metabolism as well as in the maintenance of energy homeostasis. Here we describe loss of the circadian oscillation of C/ebpα expression in liver of Clock mutant mice. Reporter assays indicate Clock and Bmal significantly induced C/ebpα gene expression whereas Cry suppressed. Real time reporter assays showed that two mutated E-boxes disrupted C/ebpα promoter dependent-oscillation. Chromatin immunoprecipitation suggests Clock can bind to two E-boxes in the C/ebpα promoter with a circadian manner in vivo. Thus, C/ebpα gene transcription is under circadian control of a core clock component, Clock. The data suggests that circadian disturbances may affect metabolic abnormalities through the C/ebpα pathway in liver." @default.
• W2014429983 created "2016-06-24" @default.
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• W2014429983 date "2013-03-11" @default.
• W2014429983 modified "2023-10-16" @default.
• W2014429983 title "The Circadian Binding of CLOCK Protein to the Promoter of C/ebpα Gene in Mouse Cells" @default.
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• W2014429983 doi "https://doi.org/10.1371/journal.pone.0058221" @default.
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