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- W2014430247 abstract "The photodynamic properties of a new hypocrellin B (HB) derivative bearing a bispyrrolecarboxamide pendant (HB-Net) were investigated in detail. EPR experiments revealed that the generation ability of reactive oxygen species (ROS) of HB-Net is inferior to that of HB. DNA melting temperature measurements and ethidium bromide (EB) displacement assay illustrated the affinity of HB-Net toward dsDNA as the result of the bispyrrolecarboxamide unit, which is structurally related to the well-known minor groove binder netropsin. The radical generation abilities of HB and HB-Net can be enhanced by ascorbic acid via the photoinduced electron transfer from ascorbic acid to the photosensitizer, however, only the DNA photodamage capability of HB-Net can be improved significantly by ascorbic acid due to the stronger affinity of HB-Net to DNA. Consequently, the combination of HB-Net and ascorbic acid may lead to efficient DNA photodamage even in anaerobic conditions." @default.
- W2014430247 created "2016-06-24" @default.
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- W2014430247 date "2008-07-23" @default.
- W2014430247 modified "2023-10-17" @default.
- W2014430247 title "Photodynamic Properties of a Bispyrrolecarboxamide-Modified Hypocrellin B: The Role of Affinity and Ascorbic Acid" @default.
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- W2014430247 doi "https://doi.org/10.1021/jp7121467" @default.
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