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• W2014435786 abstract "Previous work by Cellerino et al. has shown that chronic absence of brain-derived neurotrophic factor (BDNF) resulted in hypomyelination of the optic nerve. Since myelination is influenced by neuronal activity, it is possible that a deficiency in BDNF during early development could alter the firing properties of retinal neurons. To test this hypothesis, patch-clamp recordings were performed in retinal whole mounts from BDNF-deficient (bdnf−/−), heterozygote (bdnf+/−) or wild-type control mice (bdnf+/+). Ganglion cell layer neurons (RGNs) were tested at different age [postnatal day (P)1–11] for their ability to encode graded depolarization with variable action potential frequency. At all developmental ages examined, RGNs exhibiting frequency coding were less frequently encountered in bdnf−/− than in bdnf+/+ mice. At P1, none of the RGNs from bdnf−/− mice displayed repetitive firing compared to 50% in bdnf+/+ mice, and by P7–11, only 50% of bdnf−/− RGNs exhibited repetitive firing compared to 100% in bdnf+/+ mice. Moreover, in bdnf−/− RGNs repetitive discharge was characterized by a reduced frequency increment per current change. Acquisition of repetitive firing was paralleled by a decrease in input resistance and a steep increase of sodium current density. In bdnf−/− mice, the onset of this increase occurred at later stages of development than in wild-type controls (bdnf−/−: P6–11; bdnf+/+: P2–6). The discharge pattern of P7–11 bdnf−/− RGNs resembled that of RGNs in neonatal wild-type mice and was mimicked by acute application of a Ca2+ channel blocker. We conclude that BDNF plays an important role in the ontogeny of repetitive firing of RGNs. © 1999 John Wiley & Sons, Inc. J Neurobiol 40: 407–419, 1999" @default.
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• W2014435786 date "1999-09-05" @default.
• W2014435786 modified "2023-10-16" @default.
• W2014435786 title "Repetitive firing deficits and reduced sodium current density in retinal ganglion cells developing in the absence of BDNF" @default.
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• W2014435786 doi "https://doi.org/10.1002/(sici)1097-4695(19990905)40:3<407::aid-neu12>3.0.co;2-t" @default.
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