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• W2014445965 abstract "The effects on motivation to eat and food intake of administering small amounts of aspartame (234 to 470 mg: lower dose equivalent to the amount of aspartame contained in 1-2 cans of some soft drinks) in capsules to human volunteers were examined in two separate experiments (the second was a replication of the first). The results provided clear evidence of a prominent postingestive inhibitory action of aspartame on appetite: consumed in capsules, aspartame reduced subsequent food intake and, to a lesser extent, motivation to eat. The mechanism underlying this effect has yet to be elucidated. A possibility is that the release of cholecystokinin by phenylalanine, a constituent of aspartame, is involved. A further result was that drinking aspartame-sweetened water did not reliably reduce motivational ratings or food intake (in the first experiment aspartame ingested in capsules significantly reduced food intake compared with the same amount ingested as a sweet drink). One interpretation of these together with previous findings is that the response to consuming aspartame is determined by at least two interacting influences: an inhibitory postingestive effect and a stimulatory effect of its sweet taste. In turn, the relative potency of these influences may be modified by certain other features of the aspartame-sweetened food or drink (e.g., its nutrient content). Another implication of these results is that it cannot be assumed that intense sweeteners will all have equivalent effects on appetite." @default.
• W2014445965 created "2016-06-24" @default.
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• W2014445965 date "1990-06-01" @default.
• W2014445965 modified "2023-10-14" @default.
• W2014445965 title "Aspartame ingested without tasting inhibits hunger and food intake" @default.
• W2014445965 cites W1914805568 @default.
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• W2014445965 doi "https://doi.org/10.1016/0031-9384(90)90377-g" @default.
• W2014445965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2395929" @default.
• W2014445965 hasPublicationYear "1990" @default.
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