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- W201444682 abstract "In the sphere of gynaecological malignancies, the chemotherapeutic management of advanced cervical cancer is exceptionally challenging. Significantly, the slow pace in the evolution of novel targeted therapies in treating this disease partly explains why it remains third only to breast and ovarian cancer in terms of female cancer mortality worldwide. Over the course of the past decade, only small increments in overall and progression-free survival using combination chemotherapy has been witnessed, with the doublet of platinum-agents plus paclitaxel becoming established as the optimal first-line regimen. However the median overall survival still remains desperately poor ranging between 9-18 months. With the recent explosion of adjunctive molecular targeted agents alongside chemotherapy, there has been significant scope for their inclusion into the treatment paradigms for locally advanced, recurrent and metastatic cervical cancer. Considerable impacts have been made by scrutinising the way in which signal transduction pathways can be modulated to improve survival in this setting. Specifically, bevacizumab and other agents targeting vascular endothelial growth factor (VEGF) have returned promising results, prompting a plethora of early-phase trials. Other areas of burgeoning interest include inhibition of epithelial growth factor receptor (EGFR), platelet-derived growth factor (PDGF), mammalian target of rapamycin (mTOR), histone deacetylase (HDAC),cyclooxygenase (COX), insulin growth factor receptor (IGFR) and activators of AMP kinase (AMPK). Currently, these areas represent exciting new frontiers in advanced cervical cancer management, having already proven a substantial benefit in other numerous tumour types. Though they are yet to make the leap from publication to clinical practice, targeted therapies undoubtedly point the way forward. This chapter aims to outline the current evidence to support their swift introduction in this grave disease, drawing on literature from in vitro and in vivo studies and also highlights the possible reasons for the paucity of clinical trials focused on the incorporation of agents that have shown efficacy in other gynaecological tumours." @default.
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- W201444682 date "2013-01-01" @default.
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- W201444682 title "Targeted therapeutic management of locally advanced, recurrent and metastatic cervical cancer" @default.
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