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- W2014453629 abstract "Lafutidine is a novel histamine H2-receptor antagonist with a potent and long-lasting anti-acid secretory effect that has also been found to have a potent gastroprotective effect. We investigated the effect of lafutidine on gastric mucosal injury induced in rats with the use of water-immersion restraint stress (WRS) by examining serum calcitonin gene-related peptide (CGRP) concentrations, which we measured with the use of an enzyme immunometric assay. WRS-induced mucosal erosive injury in the stomach was reduced significantly by both lafutidine and famotidine pretreatment (from 7.79 ± 2.02 mm2 to 3.09 ± 0.74 mm2 and 4.05 ± 1.18 mm2, respectively). A single administration of lafutidine or famotidine did not change the serum CGRP concentration from the control value when these drugs were administered without WRS. Lafutidine pretreatment before WRS caused a significant increase in serum CGRP concentration compared with famotidine (lafutidine, 86.64 ± 9.52 pg/mL; famotidine, 47.55 ± 4.35 pg/mL; control, 58.43 ± 6.07 pg/mL). Our results suggest that lafutidine augments CGRP release from the rat stomach when administered before the induction of WRS. (J Lab Clin Med 2003;141:102-5)" @default.
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- W2014453629 date "2003-02-01" @default.
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- W2014453629 title "Lafutidine, a novel histamine H2-receptor antagonist, increases serum calcitonin gene-related peptide in rats after water immersion-restraint stress" @default.
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- W2014453629 doi "https://doi.org/10.1067/mlc.2003.12" @default.
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