FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014453984> ?p ?o ?g. }

• W2014453984 endingPage "2529" @default.
• W2014453984 startingPage "2520" @default.
• W2014453984 abstract "We evaluated two human immunodeficiency virus (HIV) protease inhibitors, atazanavir (ATV) and darunavir (DRV), for pH-dependent solubility, lipid binding, and drug release from lipid nanoparticles (LNPs). Both ATV and DRV incorporated into LNPs composed of pegylated and non-pegylated phospholipids with nearly 100% efficiency, but only ATV-LNPs formed stable lipid–drug particles and exhibited pH-dependent drug release. DRV-LNPs were unstable and formed mixed micelles at low drug–lipid concentrations, and thus are not suitable for lipid–drug particle development. When ATV-LNPs were prepared with ritonavir (RTV), a metabolic and cellular membrane exporter inhibitor, and tenofovir (TFV), an HIV reverse-transcriptase inhibitor, stable, scalable, and reproducible anti-HIV drug combination LNPs were produced. Drug incorporation efficiencies of 85.5 ± 8.2, 85.1 ± 7.1, and 6.1 ± 0.8% for ATV, RTV, and TFV, respectively, were achieved. Preliminary primate pharmacokinetic studies with these pH-responsive anti-HIV drug combination LNPs administered subcutaneously produced detectable plasma concentrations that lasted for 7 days for all three drugs. These anti-HIV LNPs could be developed as a long-acting targeted antiretroviral therapy. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:2520–2529, 2014" @default.
• W2014453984 created "2016-06-24" @default.
• W2014453984 creator A5013904676 @default.
• W2014453984 creator A5038242680 @default.
• W2014453984 creator A5045487241 @default.
• W2014453984 creator A5052627502 @default.
• W2014453984 creator A5073247340 @default.
• W2014453984 date "2014-08-01" @default.
• W2014453984 modified "2023-09-29" @default.
• W2014453984 title "Evaluation of Atazanavir and Darunavir Interactions with Lipids for Developing pH-Responsive Anti-HIV Drug Combination Nanoparticles" @default.
• W2014453984 cites W1966652107 @default.
• W2014453984 cites W1975390510 @default.
• W2014453984 cites W1980915827 @default.
• W2014453984 cites W1993020322 @default.
• W2014453984 cites W2001825873 @default.
• W2014453984 cites W2010586460 @default.
• W2014453984 cites W2011616319 @default.
• W2014453984 cites W2017814330 @default.
• W2014453984 cites W2049361389 @default.
• W2014453984 cites W2061800084 @default.
• W2014453984 cites W2064140898 @default.
• W2014453984 cites W2064546283 @default.
• W2014453984 cites W2065817859 @default.
• W2014453984 cites W2076339980 @default.
• W2014453984 cites W2078452445 @default.
• W2014453984 cites W2090009204 @default.
• W2014453984 cites W2095008938 @default.
• W2014453984 cites W2103075513 @default.
• W2014453984 cites W2103513664 @default.
• W2014453984 cites W2113497618 @default.
• W2014453984 cites W2114654929 @default.
• W2014453984 cites W2145507045 @default.
• W2014453984 cites W2154473573 @default.
• W2014453984 cites W2155106983 @default.
• W2014453984 cites W2163351828 @default.
• W2014453984 cites W2171236519 @default.
• W2014453984 cites W2318289184 @default.
• W2014453984 cites W2321731154 @default.
• W2014453984 cites W2339219218 @default.
• W2014453984 cites W4246432387 @default.
• W2014453984 doi "https://doi.org/10.1002/jps.24046" @default.
• W2014453984 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4349556" @default.
• W2014453984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24948204" @default.
• W2014453984 hasPublicationYear "2014" @default.
• W2014453984 type Work @default.
• W2014453984 sameAs 2014453984 @default.
• W2014453984 citedByCount "28" @default.
• W2014453984 countsByYear W20144539842015 @default.
• W2014453984 countsByYear W20144539842016 @default.
• W2014453984 countsByYear W20144539842017 @default.
• W2014453984 countsByYear W20144539842018 @default.
• W2014453984 countsByYear W20144539842019 @default.
• W2014453984 countsByYear W20144539842020 @default.
• W2014453984 countsByYear W20144539842021 @default.
• W2014453984 countsByYear W20144539842022 @default.
• W2014453984 countsByYear W20144539842023 @default.
• W2014453984 crossrefType "journal-article" @default.
• W2014453984 hasAuthorship W2014453984A5013904676 @default.
• W2014453984 hasAuthorship W2014453984A5038242680 @default.
• W2014453984 hasAuthorship W2014453984A5045487241 @default.
• W2014453984 hasAuthorship W2014453984A5052627502 @default.
• W2014453984 hasAuthorship W2014453984A5073247340 @default.
• W2014453984 hasBestOaLocation W20144539842 @default.
• W2014453984 hasConcept C108215921 @default.
• W2014453984 hasConcept C112705442 @default.
• W2014453984 hasConcept C142462285 @default.
• W2014453984 hasConcept C159047783 @default.
• W2014453984 hasConcept C181199279 @default.
• W2014453984 hasConcept C185592680 @default.
• W2014453984 hasConcept C2776714187 @default.
• W2014453984 hasConcept C2777583353 @default.
• W2014453984 hasConcept C2778414717 @default.
• W2014453984 hasConcept C2779182219 @default.
• W2014453984 hasConcept C2779298103 @default.
• W2014453984 hasConcept C2780035454 @default.
• W2014453984 hasConcept C2993143319 @default.
• W2014453984 hasConcept C3013748606 @default.
• W2014453984 hasConcept C55493867 @default.
• W2014453984 hasConcept C71924100 @default.
• W2014453984 hasConcept C98274493 @default.
• W2014453984 hasConceptScore W2014453984C108215921 @default.
• W2014453984 hasConceptScore W2014453984C112705442 @default.
• W2014453984 hasConceptScore W2014453984C142462285 @default.
• W2014453984 hasConceptScore W2014453984C159047783 @default.
• W2014453984 hasConceptScore W2014453984C181199279 @default.
• W2014453984 hasConceptScore W2014453984C185592680 @default.
• W2014453984 hasConceptScore W2014453984C2776714187 @default.
• W2014453984 hasConceptScore W2014453984C2777583353 @default.
• W2014453984 hasConceptScore W2014453984C2778414717 @default.
• W2014453984 hasConceptScore W2014453984C2779182219 @default.
• W2014453984 hasConceptScore W2014453984C2779298103 @default.
• W2014453984 hasConceptScore W2014453984C2780035454 @default.
• W2014453984 hasConceptScore W2014453984C2993143319 @default.
• W2014453984 hasConceptScore W2014453984C3013748606 @default.
• W2014453984 hasConceptScore W2014453984C55493867 @default.
• W2014453984 hasConceptScore W2014453984C71924100 @default.
• W2014453984 hasConceptScore W2014453984C98274493 @default.
• W2014453984 hasFunder F4320332161 @default.

• next