FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014454923> ?p ?o ?g. }

• W2014454923 endingPage "679" @default.
• W2014454923 startingPage "676" @default.
• W2014454923 abstract "1. It has been observed that dipyridamole (DIP) administration produces equivalent cardiovascular effects at lower systemic adenosine (ADO) plasma concentrations than those obtained with exogenous ADO infusion. This observation led to the identification of DIP for additional 'ischaemia-inducing' mechanisms, possibly based on sympathetic activation. 2. In turn, exogenous ADO administration has proven to elicit a complex neurohumoral response, including an increase in the plasma concentration of catecholamines, associated with augmented levels of the vasoactive peptides calcitonin gene-related peptide (CGRP) and atrial natriuretic peptide (ANP). More particularly, increases in CGRP seem to be dependent on sympathetic activation, while changes in ANP do not. 3. In order to clarify some aspects of the activity of DIP on neurohumoral systems, the effects of administration of DIP and ADO on plasma levels of noradrenaline (NA), CGRP and ANP were studied in healthy volunteers. Haemodynamic parameters were also monitored. 4. Infusion of exogenous ADO produced plasma levels of ADO as high as 1893+/-386 nmol/L, together with a significant increase in plasma levels of CGRP, ANP and NA. Similarly, the infusion of DIP produced augmented plasma concentrations of the examined parameters, with a peak plasma ADO concentration of 470+/-49 nmol/L. 5. At a given ADO plasma concentration of 450+/-10 nmol/L, the increase in CGRP and NA levels with DIP infusion was significantly higher than that observed following the infusion of ADO, whereas the increase in the plasma concentration of ANP following DIP infusion was very similar to that seen following ADO infusion. 6. The physiological background of these findings is based on evidence that DIP displays a greater sympathoexcitatory activity than does exogenous ADO and only the increase in plasma CGRP seems to be mediated, although indirectly, by beta-adrenoceptor stimulation. The exact mechanism of DIP-dependent sympathetic activation remains to be elucidated." @default.
• W2014454923 created "2016-06-24" @default.
• W2014454923 creator A5016224733 @default.
• W2014454923 creator A5027061253 @default.
• W2014454923 creator A5046408327 @default.
• W2014454923 creator A5075801309 @default.
• W2014454923 date "2000-09-14" @default.
• W2014454923 modified "2023-09-25" @default.
• W2014454923 title "Effects Of Dipyridamole And Adenosine On Vasoactive Peptides Calcitonin Gene-Related Peptide And Atrial Natriuretic Peptide In Humans: Role Of Sympathetic Activation" @default.
• W2014454923 cites W1968536539 @default.
• W2014454923 cites W1988032789 @default.
• W2014454923 cites W2004086945 @default.
• W2014454923 cites W2014077895 @default.
• W2014454923 cites W2015531406 @default.
• W2014454923 cites W2036941452 @default.
• W2014454923 cites W2044036181 @default.
• W2014454923 cites W2054710495 @default.
• W2014454923 cites W2078328099 @default.
• W2014454923 cites W2091485201 @default.
• W2014454923 cites W2130210592 @default.
• W2014454923 cites W2148277566 @default.
• W2014454923 cites W2277330739 @default.
• W2014454923 cites W2463296047 @default.
• W2014454923 cites W4253039236 @default.
• W2014454923 doi "https://doi.org/10.1046/j.1440-1681.2000.03324.x" @default.
• W2014454923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10972531" @default.
• W2014454923 hasPublicationYear "2000" @default.
• W2014454923 type Work @default.
• W2014454923 sameAs 2014454923 @default.
• W2014454923 citedByCount "2" @default.
• W2014454923 crossrefType "journal-article" @default.
• W2014454923 hasAuthorship W2014454923A5016224733 @default.
• W2014454923 hasAuthorship W2014454923A5027061253 @default.
• W2014454923 hasAuthorship W2014454923A5046408327 @default.
• W2014454923 hasAuthorship W2014454923A5075801309 @default.
• W2014454923 hasConcept C118303440 @default.
• W2014454923 hasConcept C126322002 @default.
• W2014454923 hasConcept C134018914 @default.
• W2014454923 hasConcept C163170386 @default.
• W2014454923 hasConcept C170493617 @default.
• W2014454923 hasConcept C185592680 @default.
• W2014454923 hasConcept C2775915353 @default.
• W2014454923 hasConcept C2776991684 @default.
• W2014454923 hasConcept C2778069365 @default.
• W2014454923 hasConcept C2778198053 @default.
• W2014454923 hasConcept C2779627488 @default.
• W2014454923 hasConcept C56191518 @default.
• W2014454923 hasConcept C71924100 @default.
• W2014454923 hasConcept C8330315 @default.
• W2014454923 hasConceptScore W2014454923C118303440 @default.
• W2014454923 hasConceptScore W2014454923C126322002 @default.
• W2014454923 hasConceptScore W2014454923C134018914 @default.
• W2014454923 hasConceptScore W2014454923C163170386 @default.
• W2014454923 hasConceptScore W2014454923C170493617 @default.
• W2014454923 hasConceptScore W2014454923C185592680 @default.
• W2014454923 hasConceptScore W2014454923C2775915353 @default.
• W2014454923 hasConceptScore W2014454923C2776991684 @default.
• W2014454923 hasConceptScore W2014454923C2778069365 @default.
• W2014454923 hasConceptScore W2014454923C2778198053 @default.
• W2014454923 hasConceptScore W2014454923C2779627488 @default.
• W2014454923 hasConceptScore W2014454923C56191518 @default.
• W2014454923 hasConceptScore W2014454923C71924100 @default.
• W2014454923 hasConceptScore W2014454923C8330315 @default.
• W2014454923 hasIssue "9" @default.
• W2014454923 hasLocation W20144549231 @default.
• W2014454923 hasLocation W20144549232 @default.
• W2014454923 hasOpenAccess W2014454923 @default.
• W2014454923 hasPrimaryLocation W20144549231 @default.
• W2014454923 hasRelatedWork W1547687776 @default.
• W2014454923 hasRelatedWork W1943192612 @default.
• W2014454923 hasRelatedWork W1966638871 @default.
• W2014454923 hasRelatedWork W2003450342 @default.
• W2014454923 hasRelatedWork W2012982306 @default.
• W2014454923 hasRelatedWork W2020160417 @default.
• W2014454923 hasRelatedWork W2085871851 @default.
• W2014454923 hasRelatedWork W2157167868 @default.
• W2014454923 hasRelatedWork W2157280939 @default.
• W2014454923 hasRelatedWork W3024044993 @default.
• W2014454923 hasVolume "27" @default.
• W2014454923 isParatext "false" @default.
• W2014454923 isRetracted "false" @default.
• W2014454923 magId "2014454923" @default.
• W2014454923 workType "article" @default.