FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014455148> ?p ?o ?g. }

• W2014455148 endingPage "e4722" @default.
• W2014455148 startingPage "e4722" @default.
• W2014455148 abstract "Microvesicles are plasma membrane-derived vesicles released into the extracellular environment by a variety of cell types. Originally characterized from platelets, microvesicles are a normal constituent of human plasma, where they play an important role in maintaining hematostasis. Microvesicles have been shown to transfer proteins and RNA from cell to cell and they are also believed to play a role in intercellular communication. We characterized the RNA and protein content of embryonic stem cell microvesicles and show that they can be engineered to carry exogenously expressed mRNA and protein such as green fluorescent protein (GFP). We demonstrate that these engineered microvesicles dock and fuse with other embryonic stem cells, transferring their GFP. Additionally, we show that embryonic stem cells microvesicles contain abundant microRNA and that they can transfer a subset of microRNAs to mouse embryonic fibroblasts in vitro. Since microRNAs are short (21-24 nt), naturally occurring RNAs that regulate protein translation, our findings open up the intriguing possibility that stem cells can alter the expression of genes in neighboring cells by transferring microRNAs contained in microvesicles. Embryonic stem cell microvesicles may be useful therapeutic tools for transferring mRNA, microRNAs, protein, and siRNA to cells and may be important mediators of signaling within stem cell niches." @default.
• W2014455148 created "2016-06-24" @default.
• W2014455148 creator A5024126113 @default.
• W2014455148 creator A5024294571 @default.
• W2014455148 creator A5026064711 @default.
• W2014455148 creator A5051625501 @default.
• W2014455148 creator A5052978402 @default.
• W2014455148 creator A5064598897 @default.
• W2014455148 creator A5074173282 @default.
• W2014455148 date "2009-03-06" @default.
• W2014455148 modified "2023-10-10" @default.
• W2014455148 title "Transfer of MicroRNAs by Embryonic Stem Cell Microvesicles" @default.
• W2014455148 cites W1483942058 @default.
• W2014455148 cites W1522558402 @default.
• W2014455148 cites W1555041989 @default.
• W2014455148 cites W1593965037 @default.
• W2014455148 cites W1967367827 @default.
• W2014455148 cites W1972070926 @default.
• W2014455148 cites W1973699456 @default.
• W2014455148 cites W1973876456 @default.
• W2014455148 cites W1976681765 @default.
• W2014455148 cites W1992041389 @default.
• W2014455148 cites W1992941735 @default.
• W2014455148 cites W2003722940 @default.
• W2014455148 cites W2017044435 @default.
• W2014455148 cites W2020833650 @default.
• W2014455148 cites W2024000520 @default.
• W2014455148 cites W2084687787 @default.
• W2014455148 cites W2086275775 @default.
• W2014455148 cites W2088738576 @default.
• W2014455148 cites W2102453345 @default.
• W2014455148 cites W2107277218 @default.
• W2014455148 cites W2112187582 @default.
• W2014455148 cites W2113975222 @default.
• W2014455148 cites W2138664009 @default.
• W2014455148 cites W2139491529 @default.
• W2014455148 cites W2150761119 @default.
• W2014455148 cites W2151922790 @default.
• W2014455148 cites W2152936026 @default.
• W2014455148 cites W2153982586 @default.
• W2014455148 cites W2156887090 @default.
• W2014455148 cites W2157194244 @default.
• W2014455148 cites W2160467221 @default.
• W2014455148 cites W2161222316 @default.
• W2014455148 cites W2162159732 @default.
• W2014455148 cites W2167557255 @default.
• W2014455148 doi "https://doi.org/10.1371/journal.pone.0004722" @default.
• W2014455148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2648987" @default.
• W2014455148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19266099" @default.
• W2014455148 hasPublicationYear "2009" @default.
• W2014455148 type Work @default.
• W2014455148 sameAs 2014455148 @default.
• W2014455148 citedByCount "388" @default.
• W2014455148 countsByYear W20144551482012 @default.
• W2014455148 countsByYear W20144551482013 @default.
• W2014455148 countsByYear W20144551482014 @default.
• W2014455148 countsByYear W20144551482015 @default.
• W2014455148 countsByYear W20144551482016 @default.
• W2014455148 countsByYear W20144551482017 @default.
• W2014455148 countsByYear W20144551482018 @default.
• W2014455148 countsByYear W20144551482019 @default.
• W2014455148 countsByYear W20144551482020 @default.
• W2014455148 countsByYear W20144551482021 @default.
• W2014455148 countsByYear W20144551482022 @default.
• W2014455148 countsByYear W20144551482023 @default.
• W2014455148 crossrefType "journal-article" @default.
• W2014455148 hasAuthorship W2014455148A5024126113 @default.
• W2014455148 hasAuthorship W2014455148A5024294571 @default.
• W2014455148 hasAuthorship W2014455148A5026064711 @default.
• W2014455148 hasAuthorship W2014455148A5051625501 @default.
• W2014455148 hasAuthorship W2014455148A5052978402 @default.
• W2014455148 hasAuthorship W2014455148A5064598897 @default.
• W2014455148 hasAuthorship W2014455148A5074173282 @default.
• W2014455148 hasBestOaLocation W20144551481 @default.
• W2014455148 hasConcept C104317684 @default.
• W2014455148 hasConcept C145059251 @default.
• W2014455148 hasConcept C145103041 @default.
• W2014455148 hasConcept C1491633281 @default.
• W2014455148 hasConcept C189014844 @default.
• W2014455148 hasConcept C20518536 @default.
• W2014455148 hasConcept C2781261824 @default.
• W2014455148 hasConcept C28328180 @default.
• W2014455148 hasConcept C54355233 @default.
• W2014455148 hasConcept C86803240 @default.
• W2014455148 hasConcept C95444343 @default.
• W2014455148 hasConceptScore W2014455148C104317684 @default.
• W2014455148 hasConceptScore W2014455148C145059251 @default.
• W2014455148 hasConceptScore W2014455148C145103041 @default.
• W2014455148 hasConceptScore W2014455148C1491633281 @default.
• W2014455148 hasConceptScore W2014455148C189014844 @default.
• W2014455148 hasConceptScore W2014455148C20518536 @default.
• W2014455148 hasConceptScore W2014455148C2781261824 @default.
• W2014455148 hasConceptScore W2014455148C28328180 @default.
• W2014455148 hasConceptScore W2014455148C54355233 @default.
• W2014455148 hasConceptScore W2014455148C86803240 @default.
• W2014455148 hasConceptScore W2014455148C95444343 @default.
• W2014455148 hasIssue "3" @default.
• W2014455148 hasLocation W20144551481 @default.

• next