FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W201445770> ?p ?o ?g. }

• W201445770 abstract "In spontaneously hypertensive rats (SHR) the hypersensitivity of the renal vasculature to angiotensin II (Ang II), compared to Wistar-Kyoto rats (WKY), appears to be the determining factor in the development and progression of hypertension. Recent evidence indicates that the ERK cascade and NAD(P)H oxidase generation of superoxide are involved in smooth muscle contraction, and Phospholipase D (PLD) generation of phosphatidic acid is involved in activation of ERK and NAD(P)H. Importantly, Ang II-mediated PLD activity is greater in aortic smooth muscle from SHR compared with WKY; however, this signaling pathway has not been examined in the kidney vasculature. The purpose of these studies were to define Ang II-mediated signal transduction mechanism(s) involved in PLD regulation in WKY and SHR preglomerular smooth muscle cells (PGSMCs). The goals of this study were to determine: 1) whether Ang II-mediated PLD activity is greater in SHR; 2) the Ang II signaling pathway(s) responsible for regulating PLD activity, and whether they are altered in SHR; and 3) whether PLD-mediated generation of phosphatidic acid is involved in Ang II-induced activation of the ERK cascade. The data indicates that the mechanisms leading to activation of PLD are similar in WKY and SHR and PLD is required for Ang II activation of ERK; however, Ang II more potently activates PLD in SHR. Further analysis indicates that the AT2 receptor inhibits AT1 receptor/RhoA-dependent activation of PLD through a nitric oxide/cGMP-dependent phosphorylation of RhoA at serine 188, which promotes RhoGDI inhibition of RhoA. These experiments expose two key differences between WKY and SHR PGSMCs: 1) SHR have an increased AT1/AT2 receptor ratio; and 2) SHR are less sensitive to nitric oxide and cGMP. Therefore, the hypersensitivity of the SHR to Ang II may be due to an imbalance in Ang II receptors and/or impaired AT2 receptor-mediated signaling within the kidney vasculature." @default.
• W201445770 created "2016-06-24" @default.
• W201445770 creator A5009668864 @default.
• W201445770 date "2002-09-26" @default.
• W201445770 modified "2023-09-24" @default.
• W201445770 title "ANGIOTENSIN II SIGNALING TO PHOSPHOLIPASE D IN A MODEL OF GENETIC HYPERTENSION" @default.
• W201445770 cites W114522406 @default.
• W201445770 cites W1481438484 @default.
• W201445770 cites W1489297798 @default.
• W201445770 cites W1493531388 @default.
• W201445770 cites W1507341638 @default.
• W201445770 cites W1512964013 @default.
• W201445770 cites W1528720934 @default.
• W201445770 cites W1537459781 @default.
• W201445770 cites W1546336086 @default.
• W201445770 cites W1561131854 @default.
• W201445770 cites W1569291911 @default.
• W201445770 cites W1577261854 @default.
• W201445770 cites W1586099293 @default.
• W201445770 cites W1589391295 @default.
• W201445770 cites W1589866689 @default.
• W201445770 cites W1597787921 @default.
• W201445770 cites W1601455272 @default.
• W201445770 cites W1633066991 @default.
• W201445770 cites W164612407 @default.
• W201445770 cites W1773214071 @default.
• W201445770 cites W1789636131 @default.
• W201445770 cites W1813918 @default.
• W201445770 cites W1818334985 @default.
• W201445770 cites W1822066871 @default.
• W201445770 cites W1837479159 @default.
• W201445770 cites W1896224567 @default.
• W201445770 cites W1915650964 @default.
• W201445770 cites W1925229827 @default.
• W201445770 cites W1926745530 @default.
• W201445770 cites W1957331891 @default.
• W201445770 cites W1963817582 @default.
• W201445770 cites W1967044710 @default.
• W201445770 cites W1967345870 @default.
• W201445770 cites W1967622958 @default.
• W201445770 cites W1967625995 @default.
• W201445770 cites W1967979328 @default.
• W201445770 cites W1970245357 @default.
• W201445770 cites W1970677658 @default.
• W201445770 cites W1971646616 @default.
• W201445770 cites W1972750612 @default.
• W201445770 cites W1973624256 @default.
• W201445770 cites W1973770590 @default.
• W201445770 cites W1974030744 @default.
• W201445770 cites W1974081806 @default.
• W201445770 cites W1975199357 @default.
• W201445770 cites W1976555160 @default.
• W201445770 cites W1976695667 @default.
• W201445770 cites W1977071631 @default.
• W201445770 cites W1977951315 @default.
• W201445770 cites W1978279440 @default.
• W201445770 cites W1979073238 @default.
• W201445770 cites W1979945257 @default.
• W201445770 cites W1980182090 @default.
• W201445770 cites W1983561419 @default.
• W201445770 cites W1983616507 @default.
• W201445770 cites W1984905038 @default.
• W201445770 cites W1984906223 @default.
• W201445770 cites W1986292558 @default.
• W201445770 cites W1987909966 @default.
• W201445770 cites W1988018358 @default.
• W201445770 cites W1988642373 @default.
• W201445770 cites W1990249744 @default.
• W201445770 cites W1992628345 @default.
• W201445770 cites W1994863832 @default.
• W201445770 cites W1997449279 @default.
• W201445770 cites W1999157780 @default.
• W201445770 cites W2000816990 @default.
• W201445770 cites W2002019101 @default.
• W201445770 cites W2002111899 @default.
• W201445770 cites W2004873860 @default.
• W201445770 cites W2007375100 @default.
• W201445770 cites W2008346251 @default.
• W201445770 cites W2008924522 @default.
• W201445770 cites W2012564759 @default.
• W201445770 cites W2013690237 @default.
• W201445770 cites W2015057079 @default.
• W201445770 cites W2017304954 @default.
• W201445770 cites W2017800047 @default.
• W201445770 cites W2018149384 @default.
• W201445770 cites W2020815929 @default.
• W201445770 cites W2021327355 @default.
• W201445770 cites W2021810915 @default.
• W201445770 cites W2023578877 @default.
• W201445770 cites W2024878957 @default.
• W201445770 cites W2026039614 @default.
• W201445770 cites W2027455512 @default.
• W201445770 cites W2029954557 @default.
• W201445770 cites W2032266156 @default.
• W201445770 cites W2032295238 @default.
• W201445770 cites W2035493043 @default.
• W201445770 cites W2036176695 @default.
• W201445770 cites W2038838027 @default.
• W201445770 cites W2039086575 @default.
• W201445770 cites W2039983290 @default.

• next