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• W2014457703 abstract "During vertebrate gastrulation, Wnt/planar cell polarity (PCP) signaling orchestrates polarized cell behaviors underlying convergence and extension (C&E) movements to narrow embryonic tissues mediolaterally and lengthen them anteroposteriorly. Here, we have identified Gpr125, an adhesion G protein-coupled receptor, as a novel modulator of the Wnt/PCP signaling system. Excess Gpr125 impaired C&E movements and the underlying cell and molecular polarities. Reduced Gpr125 function exacerbated the C&E and facial branchiomotor neuron (FBMN) migration defects of embryos with reduced Wnt/PCP signaling. At the molecular level, Gpr125 recruited Dishevelled to the cell membrane, a prerequisite for Wnt/PCP activation. Moreover, Gpr125 and Dvl mutually clustered one another to form discrete membrane subdomains, and the Gpr125 intracellular domain directly interacted with Dvl in pull-down assays. Intriguingly, Dvl and Gpr125 were able to recruit a subset of PCP components into membrane subdomains, suggesting that Gpr125 may modulate the composition of Wnt/PCP membrane complexes. Our study reveals a role for Gpr125 in PCP-mediated processes and provides mechanistic insight into Wnt/PCP signaling." @default.
• W2014457703 created "2016-06-24" @default.
• W2014457703 creator A5022526821 @default.
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• W2014457703 date "2013-07-15" @default.
• W2014457703 modified "2023-10-13" @default.
• W2014457703 title "Gpr125 modulates Dishevelled distribution and planar cell polarity signaling" @default.
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• W2014457703 doi "https://doi.org/10.1242/dev.094839" @default.
• W2014457703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3699285" @default.
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