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- W2014457937 abstract "G A A b st ra ct s diet alone group (p<0.05). INCB3619 significantly inhibited pEGFR and pErbB2 signals in intestinal adenomas. Colon tumor incidence was 0.33 in the INCB3619-treated group, compared to 0.83 in Western diet alone group (p=0.10). Summary INCB3619 significantly reduced intestinal tumor multiplicity and tumor size in Apc Min mice. INCB3619 also concomitantly suppressed intestinal mucosal ADAM17 enzyme activity as well as EGFR signals in intestinal adenomas. Conclusions Our results show that targeting ADAM17 inhibits intestinal tumor promotion byWestern diet.We postulate thatWestern diet promotes tumorigenesis by activating ADAM17 and up-regulating EGFR signals. Our studies suggest that ADAM17 inhibitors might provide a novel strategy to reduce colon cancer risk in individuals consuming Western diets." @default.
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- W2014457937 date "2014-05-01" @default.
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- W2014457937 title "Sa1958 Serrated Polyposis Syndrome: Pushing Through Prevalence and Clinicopathological Features" @default.
- W2014457937 doi "https://doi.org/10.1016/s0016-5085(14)61228-2" @default.
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