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• W2014458538 abstract "Combined chromatographic methods led to the isolation of two new triterpenoid saponins, glochieriosides A and B (1, 2), from the aerial parts of Glochidion eriocarpum, along with three known triterpenes, glochidone (3), lup-20(29)-en-3beta,23-diol (4), and lup-20(29)-en-1beta,3beta-diol (5). The structures of the new saponins were determined to be 22beta-benzoyloxy-3beta,16beta,28-trihydroxyolean-12-ene 3-O-[beta-D-glucopyranosyl-(1-->3)-alpha-L-arabinopyranoside] (1) and 22beta-benzoyloxy-3beta,16beta,28-trihydroxyolean-12-ene 3-O-[beta-D-glucopyranosyl-(1-->3)-beta-D-xylopyranoside] (2). The structural elucidation was accomplished by using a combination of the 1D-NMR (1H-, 13C-NMR, distortionless enhancement by polarization transfer (DEPT) 90 degrees , and DEPT 135 degrees ), 2D-NMR (1H-1H correlation spectroscopy, heteronuclear multiple quantum correlation, heteronuclear multiple bond correlation, and rotating frame Overhouser effect spectroscopy), ESI-MS, and HR-FAB-MS experiments. Glochieriosides A and B exhibited significant cytotoxic activity against HL-60, HT-29, MCF-7 and SK-OV-3 human cancer cell lines with the IC50 values of 5.5, 6.8, 29.1, and 22.7 microM for glochierioside A, respectively, and 6.6, 18.6, 36.1, and 16.0 microM for glochierioside B. Glochidone was less active with IC50 values greater than 100 microM while lup-20(29)-en-1beta,3beta-diol was moderately active with IC50 values of 43.3, 67.0, 66.1, and 48.0 microM, respectively." @default.
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• W2014458538 date "2009-01-01" @default.
• W2014458538 modified "2023-10-03" @default.
• W2014458538 title "New Triterpenoid Saponins from Glochidion eriocarpum and Their Cytotoxic Activity" @default.
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• W2014458538 doi "https://doi.org/10.1248/cpb.57.102" @default.
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