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- W2014475413 abstract "Intravenous phenytoin (mean dose, 13.0 mg per kilogram of body weight) was administered to 14 patients at a rate not exceeding 100 mg per minute. Twelve hours after infusion the mean plasma phenytoin concentration was 10.2 μg per milliliter, and a therapeutic plasma concentration was found in 9 of the 14 patients. In 3 additional patients, during removal of a primary brain tumor, cortical samples were obtained after intravenous infusion of phenytoin (mean dose, 9.2 mg/kg). Rapid penetration of the brain was found. Concentrations at the end of infusion (16 μg/gm) and 60 minutes after infusion (23 μ/gm) were not significantly different. Six other patients received intravenous phenytoin (mean dose, 10.9 mg/kg) during pneumoencephalography. The cerebrospinal fluid phenytoin concentration gradually increased over 50 minutes. The plasma/cerebrospinal fluid ratio at 50 minutes was 11.0, which is approximately the ratio of total/free phenytoin in the plasma. An additional 10 patients in generalized convulsive status epilepticus were treated with intravenous phenytoin (mean dose, 12.2 mg/kg); status was controlled in 9 within 30 minutes. No major side-effects were noted. Intravenous phenytoin rapidly enters the central nervous system and results in prompt and effective treatment of status epilepticus without suppressing higher cortical function or cardiorespiratory centers." @default.
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- W2014475413 title "Efficacy of intravenous phenytoin in the treatment of status epilepticus: Kinetics of central nervous system penetration" @default.
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- W2014475413 doi "https://doi.org/10.1002/ana.410010602" @default.
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