FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014475872> ?p ?o ?g. }

• W2014475872 endingPage "1920" @default.
• W2014475872 startingPage "1912" @default.
• W2014475872 abstract "ABSTRACT Neisseria gonorrhoeae produces a type IV secretion system that secretes chromosomal DNA. The secreted DNA is active in the transformation of other gonococci in the population and may act to transfer antibiotic resistance genes and variant alleles for surface antigens, as well as other genes. We observed that gonococcal variants that produced type IV pili secreted more DNA than variants that were nonpiliated, suggesting that the process may be regulated. Using microarray analysis, we found that a piliated strain showed increased expression of the gene for the putative type IV secretion coupling protein TraD, whereas a nonpiliated variant showed increased expression of genes for transcriptional and translational machinery, consistent with its higher growth rate compared to that of the piliated strain. These results suggested that type IV secretion might be controlled by either traD expression or growth rate. A mutant with a deletion in traD was found to be deficient in DNA secretion. Further mutation and complementation analysis indicated that traD is transcriptionally and translationally coupled to traI , which encodes the type IV secretion relaxase. We were able to increase DNA secretion in a nonpiliated strain by inserting a gene cassette with a strong promoter to drive the expression of the putative operon containing traI and traD . Together, these data suggest a model in which the type IV secretion system apparatus is made constitutively, while its activity is controlled through regulation of traD and traI ." @default.
• W2014475872 created "2016-06-24" @default.
• W2014475872 creator A5030198839 @default.
• W2014475872 creator A5053607368 @default.
• W2014475872 creator A5057771930 @default.
• W2014475872 creator A5065853714 @default.
• W2014475872 creator A5069776475 @default.
• W2014475872 creator A5084479884 @default.
• W2014475872 date "2010-04-01" @default.
• W2014475872 modified "2023-09-29" @default.
• W2014475872 title "Increased Expression of the Type IV Secretion System in Piliated <i>Neisseria gonorrhoeae</i> Variants" @default.
• W2014475872 cites W1489188014 @default.
• W2014475872 cites W1524005751 @default.
• W2014475872 cites W1525570188 @default.
• W2014475872 cites W1594008356 @default.
• W2014475872 cites W1774452618 @default.
• W2014475872 cites W1779768799 @default.
• W2014475872 cites W1781864281 @default.
• W2014475872 cites W1844067927 @default.
• W2014475872 cites W1851892282 @default.
• W2014475872 cites W1855475827 @default.
• W2014475872 cites W1964447229 @default.
• W2014475872 cites W1978413629 @default.
• W2014475872 cites W1981928038 @default.
• W2014475872 cites W1989046893 @default.
• W2014475872 cites W1994591309 @default.
• W2014475872 cites W2008068279 @default.
• W2014475872 cites W2011747306 @default.
• W2014475872 cites W2059577882 @default.
• W2014475872 cites W2061336501 @default.
• W2014475872 cites W2079212337 @default.
• W2014475872 cites W2094440115 @default.
• W2014475872 cites W2097785287 @default.
• W2014475872 cites W2100740117 @default.
• W2014475872 cites W2106889520 @default.
• W2014475872 cites W2112985866 @default.
• W2014475872 cites W2113200077 @default.
• W2014475872 cites W2113448488 @default.
• W2014475872 cites W2116475900 @default.
• W2014475872 cites W2119978464 @default.
• W2014475872 cites W2122415014 @default.
• W2014475872 cites W2124584113 @default.
• W2014475872 cites W2124664358 @default.
• W2014475872 cites W2125387019 @default.
• W2014475872 cites W2130347102 @default.
• W2014475872 cites W2130499054 @default.
• W2014475872 cites W2132335815 @default.
• W2014475872 cites W2132878899 @default.
• W2014475872 cites W2135771899 @default.
• W2014475872 cites W2136892795 @default.
• W2014475872 cites W2137575372 @default.
• W2014475872 cites W2138142090 @default.
• W2014475872 cites W2138571988 @default.
• W2014475872 cites W2144254383 @default.
• W2014475872 cites W2144572563 @default.
• W2014475872 cites W2147268470 @default.
• W2014475872 cites W2147302347 @default.
• W2014475872 cites W2150203465 @default.
• W2014475872 cites W2151829625 @default.
• W2014475872 cites W2158641740 @default.
• W2014475872 cites W2161085554 @default.
• W2014475872 cites W2165946618 @default.
• W2014475872 cites W2168867828 @default.
• W2014475872 cites W2172209658 @default.
• W2014475872 cites W58301220 @default.
• W2014475872 doi "https://doi.org/10.1128/jb.01357-09" @default.
• W2014475872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2838043" @default.
• W2014475872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20139191" @default.
• W2014475872 hasPublicationYear "2010" @default.
• W2014475872 type Work @default.
• W2014475872 sameAs 2014475872 @default.
• W2014475872 citedByCount "29" @default.
• W2014475872 countsByYear W20144758722012 @default.
• W2014475872 countsByYear W20144758722013 @default.
• W2014475872 countsByYear W20144758722014 @default.
• W2014475872 countsByYear W20144758722015 @default.
• W2014475872 countsByYear W20144758722016 @default.
• W2014475872 countsByYear W20144758722017 @default.
• W2014475872 countsByYear W20144758722019 @default.
• W2014475872 countsByYear W20144758722021 @default.
• W2014475872 countsByYear W20144758722022 @default.
• W2014475872 countsByYear W20144758722023 @default.
• W2014475872 crossrefType "journal-article" @default.
• W2014475872 hasAuthorship W2014475872A5030198839 @default.
• W2014475872 hasAuthorship W2014475872A5053607368 @default.
• W2014475872 hasAuthorship W2014475872A5057771930 @default.
• W2014475872 hasAuthorship W2014475872A5065853714 @default.
• W2014475872 hasAuthorship W2014475872A5069776475 @default.
• W2014475872 hasAuthorship W2014475872A5084479884 @default.
• W2014475872 hasBestOaLocation W20144758722 @default.
• W2014475872 hasConcept C104317684 @default.
• W2014475872 hasConcept C143065580 @default.
• W2014475872 hasConcept C153911025 @default.
• W2014475872 hasConcept C174832134 @default.
• W2014475872 hasConcept C188082640 @default.
• W2014475872 hasConcept C203075996 @default.
• W2014475872 hasConcept C207583985 @default.
• W2014475872 hasConcept C22744801 @default.

• next