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- W2014484261 abstract "Lung cancer biology has traditionally focused on genomic and epigenomic deregulation of protein-coding genes to identify oncogenes and tumor suppressors diagnostic and therapeutic targets. Another important layer of cancer biology has emerged in the form of noncoding RNAs (ncRNAs), which are major regulators of key cellular processes such as proliferation, RNA splicing, gene regulation, and apoptosis. In the past decade, microRNAs (miRNAs) have moved to the forefront of ncRNA cancer research, while the role of long noncoding RNAs (lncRNAs) is emerging. Here we review the mechanisms by which miRNAs and lncRNAs are deregulated in lung cancer, the technologies that can be applied to detect such alterations, and the clinical potential of these RNA species. An improved comprehension of lung cancer biology will come through the understanding of the interplay between deregulation of non-coding RNAs, the protein-coding genes they regulate, and how these interactions influence cellular networks and signalling pathways." @default.
- W2014484261 created "2016-06-24" @default.
- W2014484261 creator A5001151956 @default.
- W2014484261 creator A5013908616 @default.
- W2014484261 creator A5021292435 @default.
- W2014484261 creator A5056715317 @default.
- W2014484261 date "2012-07-18" @default.
- W2014484261 modified "2023-10-17" @default.
- W2014484261 title "Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications" @default.
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