FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014484940> ?p ?o ?g. }

• W2014484940 endingPage "298" @default.
• W2014484940 startingPage "294" @default.
• W2014484940 abstract "Although T790M mutation is considered to be the major mechanism of acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancer (NSCLC), its clinical implication remains undetermined.Post-progression tumor specimens were prospectively collected for T790M mutation analysis in NSCLC patients with acquired resistance to initial EGFR TKIs. Clinical features were compared between patients with and without T790M.Out of 70 cases, 36 (51%) were identified to have T790M mutation in the rebiopsy specimen. There was no difference in the pattern of disease progression, progression-free survival for initial TKIs (12.8 and 11.3 months), post-progression survival (14.7 and 14.1 months), or overall survival (43.5 and 36.8 months) in patients with and without T790M. In total, 34 patients received afatinib after post-progression biopsy as a subsequent treatment, and the response rate was 18%. The median progression-free survival for afatinib was 3.7 months for the entire group, and 3.2 and 4.6 months for the groups with and without T790M, respectively (P = 0.33).The identification of T790M as acquired resistance mechanism was clinically feasible. Although T790M had no prognostic or predictive role in the present study, further research is necessary to identify patients with T790M-mutant tumors who might benefit from newly developed T790M-specific TKIs." @default.
• W2014484940 created "2016-06-24" @default.
• W2014484940 creator A5003089475 @default.
• W2014484940 creator A5030107272 @default.
• W2014484940 creator A5030926405 @default.
• W2014484940 creator A5034739279 @default.
• W2014484940 creator A5082025437 @default.
• W2014484940 date "2013-11-01" @default.
• W2014484940 modified "2023-10-16" @default.
• W2014484940 title "Clinical implications of T790M mutation in patients with acquired resistance to EGFR tyrosine kinase inhibitors" @default.
• W2014484940 cites W1980497534 @default.
• W2014484940 cites W2002937040 @default.
• W2014484940 cites W2003984225 @default.
• W2014484940 cites W2022670843 @default.
• W2014484940 cites W2057606564 @default.
• W2014484940 cites W2063391304 @default.
• W2014484940 cites W2070380016 @default.
• W2014484940 cites W2091083398 @default.
• W2014484940 cites W2093613683 @default.
• W2014484940 cites W2097699101 @default.
• W2014484940 cites W2097775552 @default.
• W2014484940 cites W2098395191 @default.
• W2014484940 cites W2109080255 @default.
• W2014484940 cites W2110841878 @default.
• W2014484940 cites W2129736970 @default.
• W2014484940 cites W2129787264 @default.
• W2014484940 cites W2132157071 @default.
• W2014484940 cites W2133963438 @default.
• W2014484940 cites W2138089710 @default.
• W2014484940 cites W2139799027 @default.
• W2014484940 cites W2152905269 @default.
• W2014484940 cites W2154149901 @default.
• W2014484940 cites W2156560090 @default.
• W2014484940 cites W2156647409 @default.
• W2014484940 cites W2159013299 @default.
• W2014484940 cites W2169745966 @default.
• W2014484940 doi "https://doi.org/10.1016/j.lungcan.2013.08.023" @default.
• W2014484940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24035188" @default.
• W2014484940 hasPublicationYear "2013" @default.
• W2014484940 type Work @default.
• W2014484940 sameAs 2014484940 @default.
• W2014484940 citedByCount "99" @default.
• W2014484940 countsByYear W20144849402013 @default.
• W2014484940 countsByYear W20144849402014 @default.
• W2014484940 countsByYear W20144849402015 @default.
• W2014484940 countsByYear W20144849402016 @default.
• W2014484940 countsByYear W20144849402017 @default.
• W2014484940 countsByYear W20144849402018 @default.
• W2014484940 countsByYear W20144849402019 @default.
• W2014484940 countsByYear W20144849402020 @default.
• W2014484940 countsByYear W20144849402021 @default.
• W2014484940 countsByYear W20144849402022 @default.
• W2014484940 countsByYear W20144849402023 @default.
• W2014484940 crossrefType "journal-article" @default.
• W2014484940 hasAuthorship W2014484940A5003089475 @default.
• W2014484940 hasAuthorship W2014484940A5030107272 @default.
• W2014484940 hasAuthorship W2014484940A5030926405 @default.
• W2014484940 hasAuthorship W2014484940A5034739279 @default.
• W2014484940 hasAuthorship W2014484940A5082025437 @default.
• W2014484940 hasConcept C104317684 @default.
• W2014484940 hasConcept C121608353 @default.
• W2014484940 hasConcept C126322002 @default.
• W2014484940 hasConcept C143998085 @default.
• W2014484940 hasConcept C156719811 @default.
• W2014484940 hasConcept C170493617 @default.
• W2014484940 hasConcept C182707283 @default.
• W2014484940 hasConcept C2776256026 @default.
• W2014484940 hasConcept C2777930144 @default.
• W2014484940 hasConcept C2778820342 @default.
• W2014484940 hasConcept C2779438470 @default.
• W2014484940 hasConcept C2780580887 @default.
• W2014484940 hasConcept C2780586478 @default.
• W2014484940 hasConcept C42362537 @default.
• W2014484940 hasConcept C49105822 @default.
• W2014484940 hasConcept C501734568 @default.
• W2014484940 hasConcept C54355233 @default.
• W2014484940 hasConcept C71924100 @default.
• W2014484940 hasConcept C86803240 @default.
• W2014484940 hasConceptScore W2014484940C104317684 @default.
• W2014484940 hasConceptScore W2014484940C121608353 @default.
• W2014484940 hasConceptScore W2014484940C126322002 @default.
• W2014484940 hasConceptScore W2014484940C143998085 @default.
• W2014484940 hasConceptScore W2014484940C156719811 @default.
• W2014484940 hasConceptScore W2014484940C170493617 @default.
• W2014484940 hasConceptScore W2014484940C182707283 @default.
• W2014484940 hasConceptScore W2014484940C2776256026 @default.
• W2014484940 hasConceptScore W2014484940C2777930144 @default.
• W2014484940 hasConceptScore W2014484940C2778820342 @default.
• W2014484940 hasConceptScore W2014484940C2779438470 @default.
• W2014484940 hasConceptScore W2014484940C2780580887 @default.
• W2014484940 hasConceptScore W2014484940C2780586478 @default.
• W2014484940 hasConceptScore W2014484940C42362537 @default.
• W2014484940 hasConceptScore W2014484940C49105822 @default.
• W2014484940 hasConceptScore W2014484940C501734568 @default.
• W2014484940 hasConceptScore W2014484940C54355233 @default.
• W2014484940 hasConceptScore W2014484940C71924100 @default.
• W2014484940 hasConceptScore W2014484940C86803240 @default.
• W2014484940 hasIssue "2" @default.

• next