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- W2014484966 abstract "Several studies suggested the neural networks modulating aspects of emotional behaviour to be implicated in the pathophysiology of mood disorders. These networks involve the medial prefrontal cortex (MPFC) and closely related areas in the medial and caudolateral orbital cortex (medial prefrontal network), amygdala, hippocampus, and ventromedial parts of the basal ganglia, where alterations in grey matter volume and neurophysiological activity are found in cases with recurrent depressive episodes. Such findings hold major implications for models of the neurocircuits that underlie depression. In particular, evidence from lesion analysis studies suggests that MPFC and related limbic and striato-pallido-thalamic structures organize emotional expression. The aim of this paper is to review the contribution of the most relevant studies with single photon emission tomography (SPECT), positron emission tomography (PET) and magnetic resonance imaging (MRI) to the understanding of pathophysiology of major depressive disorder (MDD), with particular focus on the reversibility of functional correlates with treatment." @default.
- W2014484966 created "2016-06-24" @default.
- W2014484966 creator A5018065246 @default.
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- W2014484966 creator A5064580143 @default.
- W2014484966 creator A5074977948 @default.
- W2014484966 creator A5076471646 @default.
- W2014484966 date "2009-01-01" @default.
- W2014484966 modified "2023-10-12" @default.
- W2014484966 title "Anatomical and functional correlates in major depressive disorder: The contribution of neuroimaging studies" @default.
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