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- W2014485010 abstract "The transport of l-glutamate by lactating rat mammary gland has been examined using both tissue explants and a perfused mammary preparation. l-Glutamate uptake by mammary tissue explants was predominantly via a Na+-dependent pathway: Li+, choline+ and NMDG+ could not substitute for Na+. l-Glutamate efflux from preloaded explants was also influenced by the transmembrane Na+-gradient. These results are consistent with (Na+-glutamate) cotransport. The Na+-dependent system for l-glutamate transport in tissue explants was saturable (Km = 112.5 ± 19.7 μM; Vmax = 71.3 ± 10.4 nmol/min per g cells) and selective for anionic amino acids. Thus, d- and l-aspartate were high affinity inhibitors of l-glutamate uptake whereas neutral amino acids were relatively ineffective. d-Aspartate inhibited l-glutamate uptake in a competitive fashion. l-Glutamate uptake by the perfused mammary gland was (a) Na+-dependent (b) saturable (Km = 18.1 ± 4.9 μM; Vmax = 40.3 ± 3.7 nmol/min per g tissue) and (c) selective for anionic amino acids. The results suggest that the (Na+-glutamate) cotransporter is situated in the blood-facing aspect of the mammary epithelium." @default.
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- W2014485010 title "The mechanism of l-glutamate transport by lactating rat mammary tissue" @default.
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- W2014485010 doi "https://doi.org/10.1016/0005-2736(96)00054-5" @default.
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