FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014487071> ?p ?o ?g. }

• W2014487071 endingPage "1055" @default.
• W2014487071 startingPage "1047" @default.
• W2014487071 abstract "Simeprevir (SMV) is a once-daily (QD), oral hepatitis C virus (HCV) NS3/4A protease inhibitor approved for treatment of genotype (GT) 1 and GT4 infection. This Phase III, open-label, single-arm study (RESTORE; NCT01567735) evaluated efficacy/safety of SMV with peginterferon-α-2a/ribavirin (PR) in patients with chronic HCV GT4 infection.107 patients were included. Treatment-naïve (n=35) and prior relapse patients (n=22) received SMV 150mg QD+PR (12 weeks), followed by PR alone (12 or 36 weeks, response-guided [HCV RNA <25IU/ml detectable/undetectable at week 4 and <25IU/ml undetectable at week 12]). Prior non-responders (partial, n=10; null, n=40) received SMV/PR (12 weeks), followed by PR for 36 weeks. The primary endpoint was sustained virologic response 12 weeks after end of treatment (SVR12).Median age: 49.0years; 28.0% Black/African; 7.5% IL28B CC; 28.8% METAVIR F4. Overall, 65.4% (70/107) of patients achieved SVR12 (82.9% [29/35] treatment-naïve; 86.4% [19/22] prior relapsers; 60.0% [6/10] prior partial responders; 40.0% [16/40] prior null responders). In treatment-naïve and prior relapser patients fulfilling response-guided criteria for 24 weeks of treatment (88.6% [31/35] and 90.9% [20/22]), SVR12 rates were high: 93.5% [29/31] and 95.0% [19/20], respectively. Overall on-treatment failure and relapse rates were 23.4% (25/107) and 14.6% (12/82), respectively. Adverse events (AEs) were mainly grade 1/2; serious AEs were infrequent (4.7%) and considered unrelated to SMV.Efficacy and safety of SMV 150mg QD for 12 weeks with PR in treatment-naïve or -experienced patients with chronic HCV GT4 infection were in line with previous reports for HCV GT1 infection." @default.
• W2014487071 created "2016-06-24" @default.
• W2014487071 creator A5003622982 @default.
• W2014487071 creator A5013246678 @default.
• W2014487071 creator A5031660163 @default.
• W2014487071 creator A5033742518 @default.
• W2014487071 creator A5033751277 @default.
• W2014487071 creator A5036355580 @default.
• W2014487071 creator A5056607327 @default.
• W2014487071 creator A5059508363 @default.
• W2014487071 creator A5063172143 @default.
• W2014487071 creator A5070860490 @default.
• W2014487071 creator A5070970519 @default.
• W2014487071 creator A5071635250 @default.
• W2014487071 creator A5072839980 @default.
• W2014487071 creator A5086844845 @default.
• W2014487071 creator A5089037721 @default.
• W2014487071 date "2015-05-01" @default.
• W2014487071 modified "2023-10-18" @default.
• W2014487071 title "Efficacy and safety of simeprevir with PegIFN/ribavirin in naïve or experienced patients infected with chronic HCV genotype 4" @default.
• W2014487071 cites W1939121468 @default.
• W2014487071 cites W1963756548 @default.
• W2014487071 cites W1980390916 @default.
• W2014487071 cites W1985473671 @default.
• W2014487071 cites W1989022528 @default.
• W2014487071 cites W1990127122 @default.
• W2014487071 cites W1993907569 @default.
• W2014487071 cites W2000285638 @default.
• W2014487071 cites W2007217713 @default.
• W2014487071 cites W2007440654 @default.
• W2014487071 cites W2015803171 @default.
• W2014487071 cites W2023926449 @default.
• W2014487071 cites W2030205399 @default.
• W2014487071 cites W2048340336 @default.
• W2014487071 cites W2052005188 @default.
• W2014487071 cites W2078251659 @default.
• W2014487071 cites W2094972821 @default.
• W2014487071 cites W2096411838 @default.
• W2014487071 cites W2099758818 @default.
• W2014487071 cites W2107869979 @default.
• W2014487071 cites W2114985397 @default.
• W2014487071 cites W2127189337 @default.
• W2014487071 cites W2143244227 @default.
• W2014487071 cites W2156047935 @default.
• W2014487071 cites W2160042208 @default.
• W2014487071 cites W2160748326 @default.
• W2014487071 doi "https://doi.org/10.1016/j.jhep.2014.12.031" @default.
• W2014487071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25596313" @default.
• W2014487071 hasPublicationYear "2015" @default.
• W2014487071 type Work @default.
• W2014487071 sameAs 2014487071 @default.
• W2014487071 citedByCount "74" @default.
• W2014487071 countsByYear W20144870712015 @default.
• W2014487071 countsByYear W20144870712016 @default.
• W2014487071 countsByYear W20144870712017 @default.
• W2014487071 countsByYear W20144870712018 @default.
• W2014487071 countsByYear W20144870712019 @default.
• W2014487071 countsByYear W20144870712020 @default.
• W2014487071 countsByYear W20144870712021 @default.
• W2014487071 countsByYear W20144870712022 @default.
• W2014487071 countsByYear W20144870712023 @default.
• W2014487071 crossrefType "journal-article" @default.
• W2014487071 hasAuthorship W2014487071A5003622982 @default.
• W2014487071 hasAuthorship W2014487071A5013246678 @default.
• W2014487071 hasAuthorship W2014487071A5031660163 @default.
• W2014487071 hasAuthorship W2014487071A5033742518 @default.
• W2014487071 hasAuthorship W2014487071A5033751277 @default.
• W2014487071 hasAuthorship W2014487071A5036355580 @default.
• W2014487071 hasAuthorship W2014487071A5056607327 @default.
• W2014487071 hasAuthorship W2014487071A5059508363 @default.
• W2014487071 hasAuthorship W2014487071A5063172143 @default.
• W2014487071 hasAuthorship W2014487071A5070860490 @default.
• W2014487071 hasAuthorship W2014487071A5070970519 @default.
• W2014487071 hasAuthorship W2014487071A5071635250 @default.
• W2014487071 hasAuthorship W2014487071A5072839980 @default.
• W2014487071 hasAuthorship W2014487071A5086844845 @default.
• W2014487071 hasAuthorship W2014487071A5089037721 @default.
• W2014487071 hasConcept C126322002 @default.
• W2014487071 hasConcept C159047783 @default.
• W2014487071 hasConcept C168563851 @default.
• W2014487071 hasConcept C197934379 @default.
• W2014487071 hasConcept C203092338 @default.
• W2014487071 hasConcept C2522874641 @default.
• W2014487071 hasConcept C2776408679 @default.
• W2014487071 hasConcept C2776455275 @default.
• W2014487071 hasConcept C2778986448 @default.
• W2014487071 hasConcept C2780040827 @default.
• W2014487071 hasConcept C71924100 @default.
• W2014487071 hasConcept C90924648 @default.
• W2014487071 hasConceptScore W2014487071C126322002 @default.
• W2014487071 hasConceptScore W2014487071C159047783 @default.
• W2014487071 hasConceptScore W2014487071C168563851 @default.
• W2014487071 hasConceptScore W2014487071C197934379 @default.
• W2014487071 hasConceptScore W2014487071C203092338 @default.
• W2014487071 hasConceptScore W2014487071C2522874641 @default.
• W2014487071 hasConceptScore W2014487071C2776408679 @default.
• W2014487071 hasConceptScore W2014487071C2776455275 @default.
• W2014487071 hasConceptScore W2014487071C2778986448 @default.

• next