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• W2014489219 abstract "Esophageal squamous cell carcinoma ( ESCC ) is one of the deadliest malignancies worldwide. Y ing Y ang 1 ( YY 1), a ubiquitously expressed GLI ‐ K rüppel zinc finger transcription factor, plays a regulatory role in a variety of fundamental biological processes, such as embryonic development, growth, apoptosis, differentiation and oncogenic transformation. The purpose of this study was to investigate the expression of YY 1 in normal and cancerous esophageal tissues and its function in ESCC development. We found that the expression of YY 1 mRNA was significantly increased in the tumor tissues, compared with the para‐tissues or normal esophageal tissues. The increased expression of YY 1 in tumor samples was further confirmed by immunohistochemistry. Furthermore, the overexpression of YY 1 conferred radioresistance to the ESCC TE ‐1 cells and resulted in markedly reduced cell proliferation. Accordingly, the small interfering RNA ‐mediated silencing of YY 1 expression in TE ‐1 cells resulted in increased proliferation by enhancing the binding of P 21 to Cyclin D 1 and CDK 4, a protein complex known to mediate cell cycle progression. Moreover, besides P 21, heme oxygenase‐1 ( HO ‐1) was identified as a YY 1 downstream effector, as YY 1 stimulated HO ‐1 expression in esophageal cancer cells. YY 1 mediated biological function through transcription of HO ‐1. Forced expression of HO ‐1 could moderately suppress proliferation of TE ‐1 cells. The expression of YY 1 significantly correlated with that of HO ‐1 in ESCC tissues. Taken together, we demonstrated overexpression of YY 1 in esophageal carcinoma and identified HO ‐1 as its target." @default.
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• W2014489219 date "2013-09-05" @default.
• W2014489219 modified "2023-10-16" @default.
• W2014489219 title "Upregulation of <scp>Y</scp>ing <scp>Y</scp>ang 1 (<scp>YY</scp>1) suppresses esophageal squamous cell carcinoma development through heme oxygenase‐1" @default.
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• W2014489219 doi "https://doi.org/10.1111/cas.12248" @default.
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