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• W2014495054 startingPage "148" @default.
• W2014495054 abstract "We have reported that CD4+CD25+ T-regulatory (Treg) cells are fully activated for suppressor function in feline immunodeficiency virus (FIV)-infected cats. Studies have suggested that surface transforming growth factor-β (TGFβ; membrane TGFβ [mTGFβ]) is a feature of activated CD4+CD25+ Treg cells and may play a role in Treg homeostasis and suppressor function. Herein, we explore the role of TGFβ in feline Treg homeostasis and suppressor function and what effect FIV infection of cats might have on these processes. Stimulation of CD4+CD25− T helper (Th) cells with Concanavalin A (ConA) plus TGFβ converts them to Treg-like cells capable of suppressor function. Reverse-transcription polymerase chain reaction and flow cytometry revealed that these ConA/TGFβ-converted Treg cells upregulate Foxp3 and mTGFβ. ConA stimulation of CD4+CD25− T cells upregulates TGFβ receptor II (RII), and pretreatment of these cells with anti-TGFβ-RII antibodies blocks the TGFβ-induced conversion to Treg cells. Pretreatment of ConA/TGFβ-converted Treg cells with anti-TGFβ antibodies also abrogates their suppressor function, suggesting that Treg homeostasis and suppressor function may be mediated by mTGFβ. Finally, we show that treatment of CD4+CD25+ mTGFβ-positive Treg cells from FIV-infected cats with anti-TGFβ antibodies or treatment of ConA-stimulated CD4+CD25− Th target cells with anti-TGFβ-RII antibodies diminishes suppressor function. These data suggest that the recruitment of Treg cells from the Th pool and suppressor function of Treg cells are dependent on the TGFβ/TGFβ-RII signaling pathway and that this pathway is constitutively upregulated in asymptomatic chronically FIV-infected cats." @default.
• W2014495054 created "2016-06-24" @default.
• W2014495054 creator A5036288870 @default.
• W2014495054 creator A5046324927 @default.
• W2014495054 creator A5049918762 @default.
• W2014495054 date "2008-02-01" @default.
• W2014495054 modified "2023-09-27" @default.
• W2014495054 title "Transforming Growth Factor-β/Transforming Growth Factor-βRII Signaling May Regulate CD4+CD25+ T-Regulatory Cell Homeostasis and Suppressor Function in Feline AIDS Lentivirus Infection" @default.
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• W2014495054 doi "https://doi.org/10.1097/qai.0b013e318160df70" @default.
• W2014495054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18091047" @default.
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