Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014495114> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2014495114 endingPage "544" @default.
- W2014495114 startingPage "541" @default.
- W2014495114 abstract "The neuroendocrinology of menopause is reviewed from a comparative perspective, with emphasis on laboratory rodent models. These changes are compared by the 2011 STRAW criteria (Stages of Reproductive Aging Workshop). Ovarian cell loss begins prenatally in all mammals studied, with exponential depletion of primary follicles and oocytes in association with loss of fecundity by midlife. Rodents and humans also share progressively increasing irregularity in ovulatory cycles and increasing fetal aneuploidy as oocyte depletion become imminent. Hypothalamic impairments of the estrogen-induced surge of pituitary gonadotrophins (luteinizing hormone, LH; follicle stimulating hormone, FSH) are prominent in middle-aged rodents, but sporadic in peri-menopausal women. In aging rodents, hypothalamic impairments of the LH surge have been experimentally associated with prolonged phases of sustained estradiol (E2) and very low progesterone (P4) (‘unopposed estradiol’). Although peri-menopausal women also show hyper-estrogenic cycles, there is no indication for irreversible hypothalamic desensitization by E2. Ongoing cognitive assessments in clinical trials of estrogen therapy with and without P4 or other progestins may further inform about possible persisting effects of unopposed estrogens.This article is part of a Special Issue entitled ‘Menopause’." @default.
- W2014495114 created "2016-06-24" @default.
- W2014495114 creator A5007417059 @default.
- W2014495114 creator A5054680792 @default.
- W2014495114 creator A5084314992 @default.
- W2014495114 date "1994-07-01" @default.
- W2014495114 modified "2023-09-23" @default.
- W2014495114 title "Relation of Neuroendocrine function to reproductive decline during aging in the female rat" @default.
- W2014495114 cites W1990731599 @default.
- W2014495114 cites W2004042726 @default.
- W2014495114 cites W2009800773 @default.
- W2014495114 cites W2049229691 @default.
- W2014495114 cites W2053187221 @default.
- W2014495114 cites W2059739634 @default.
- W2014495114 cites W2071922080 @default.
- W2014495114 cites W2088113483 @default.
- W2014495114 cites W2101266059 @default.
- W2014495114 cites W2115301017 @default.
- W2014495114 cites W2133968191 @default.
- W2014495114 cites W2136286586 @default.
- W2014495114 cites W2137191809 @default.
- W2014495114 cites W2156864914 @default.
- W2014495114 cites W2159265224 @default.
- W2014495114 doi "https://doi.org/10.1016/0197-4580(94)90094-9" @default.
- W2014495114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7969737" @default.
- W2014495114 hasPublicationYear "1994" @default.
- W2014495114 type Work @default.
- W2014495114 sameAs 2014495114 @default.
- W2014495114 citedByCount "31" @default.
- W2014495114 countsByYear W20144951142013 @default.
- W2014495114 countsByYear W20144951142014 @default.
- W2014495114 countsByYear W20144951142015 @default.
- W2014495114 countsByYear W20144951142017 @default.
- W2014495114 countsByYear W20144951142022 @default.
- W2014495114 crossrefType "journal-article" @default.
- W2014495114 hasAuthorship W2014495114A5007417059 @default.
- W2014495114 hasAuthorship W2014495114A5054680792 @default.
- W2014495114 hasAuthorship W2014495114A5084314992 @default.
- W2014495114 hasConcept C126322002 @default.
- W2014495114 hasConcept C134018914 @default.
- W2014495114 hasConcept C1998276 @default.
- W2014495114 hasConcept C2777164284 @default.
- W2014495114 hasConcept C2778562196 @default.
- W2014495114 hasConcept C2778575703 @default.
- W2014495114 hasConcept C42407357 @default.
- W2014495114 hasConcept C71315377 @default.
- W2014495114 hasConcept C71924100 @default.
- W2014495114 hasConcept C86803240 @default.
- W2014495114 hasConceptScore W2014495114C126322002 @default.
- W2014495114 hasConceptScore W2014495114C134018914 @default.
- W2014495114 hasConceptScore W2014495114C1998276 @default.
- W2014495114 hasConceptScore W2014495114C2777164284 @default.
- W2014495114 hasConceptScore W2014495114C2778562196 @default.
- W2014495114 hasConceptScore W2014495114C2778575703 @default.
- W2014495114 hasConceptScore W2014495114C42407357 @default.
- W2014495114 hasConceptScore W2014495114C71315377 @default.
- W2014495114 hasConceptScore W2014495114C71924100 @default.
- W2014495114 hasConceptScore W2014495114C86803240 @default.
- W2014495114 hasIssue "4" @default.
- W2014495114 hasLocation W20144951141 @default.
- W2014495114 hasLocation W20144951142 @default.
- W2014495114 hasOpenAccess W2014495114 @default.
- W2014495114 hasPrimaryLocation W20144951141 @default.
- W2014495114 hasRelatedWork W1977698842 @default.
- W2014495114 hasRelatedWork W1981353066 @default.
- W2014495114 hasRelatedWork W1995050400 @default.
- W2014495114 hasRelatedWork W2013275608 @default.
- W2014495114 hasRelatedWork W2034402330 @default.
- W2014495114 hasRelatedWork W2059535980 @default.
- W2014495114 hasRelatedWork W2060297995 @default.
- W2014495114 hasRelatedWork W2075281791 @default.
- W2014495114 hasRelatedWork W2137815118 @default.
- W2014495114 hasRelatedWork W2142400691 @default.
- W2014495114 hasVolume "15" @default.
- W2014495114 isParatext "false" @default.
- W2014495114 isRetracted "false" @default.
- W2014495114 magId "2014495114" @default.
- W2014495114 workType "article" @default.