FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014501341> ?p ?o ?g. }

• W2014501341 endingPage "12883" @default.
• W2014501341 startingPage "12874" @default.
• W2014501341 abstract "Palmitoylation affects the trafficking, stability, aggregation, and/or functional activity of a substantial number of neuronal proteins. We identified mutations in dHIP14, the Drosophila homolog of the human palmitoyl transferase, Huntingtin-interacting protein 14 (HIP14). HIP14 was previously reported to localize primarily to Golgi and to palmitoylate the neuronal proteins synaptosome-associated protein 25 (SNAP-25), PSD-95 (postsynaptic density-95), GAD65, Synaptotagmin, and Huntingtin in mammalian neurons. We find dHIP14 to be an essential maternal effect gene required for photoreceptor synaptic transmission and for proper in vivo expression of the palmitoylated presynaptic proteins SNAP-25 and cysteine string protein. In non-neuronal cells in the fly, dHIP14 protein is found in Golgi. However, in fly neurons, we find dHIP14 primarily in presynaptic terminals, something we also observe with HIP14. In mammalian neurons, we also find a significant fraction of HIP14 colocalizing with a synaptic vesicle marker. Based on localization of the palmitoyl transferase HIP14 within the presynaptic nerve terminal, we propose palmitoylation as a possible mechanism that may be operating to rapidly regulate synaptic efficacy." @default.
• W2014501341 created "2016-06-24" @default.
• W2014501341 creator A5022103094 @default.
• W2014501341 creator A5081378606 @default.
• W2014501341 date "2007-11-21" @default.
• W2014501341 modified "2023-10-16" @default.
• W2014501341 title "<i>Drosophila</i>Huntingtin-Interacting Protein 14 Is a Presynaptic Protein Required for Photoreceptor Synaptic Transmission and Expression of the Palmitoylated Proteins Synaptosome-Associated Protein 25 and Cysteine String Protein" @default.
• W2014501341 cites W177177583 @default.
• W2014501341 cites W1811233773 @default.
• W2014501341 cites W1917049701 @default.
• W2014501341 cites W1970637513 @default.
• W2014501341 cites W1972678327 @default.
• W2014501341 cites W1987512166 @default.
• W2014501341 cites W1989308221 @default.
• W2014501341 cites W1992603978 @default.
• W2014501341 cites W1992955960 @default.
• W2014501341 cites W2011445581 @default.
• W2014501341 cites W2017196458 @default.
• W2014501341 cites W2018458016 @default.
• W2014501341 cites W2023361978 @default.
• W2014501341 cites W2031375592 @default.
• W2014501341 cites W2031976394 @default.
• W2014501341 cites W2034512365 @default.
• W2014501341 cites W2036312848 @default.
• W2014501341 cites W2041882228 @default.
• W2014501341 cites W2043867460 @default.
• W2014501341 cites W2048559110 @default.
• W2014501341 cites W2059843465 @default.
• W2014501341 cites W2060250513 @default.
• W2014501341 cites W2066036926 @default.
• W2014501341 cites W2098562669 @default.
• W2014501341 cites W2115734610 @default.
• W2014501341 cites W2123859931 @default.
• W2014501341 cites W2124772147 @default.
• W2014501341 cites W2133411939 @default.
• W2014501341 cites W2138136052 @default.
• W2014501341 cites W2145075118 @default.
• W2014501341 cites W2149480441 @default.
• W2014501341 cites W2152773842 @default.
• W2014501341 cites W2158179560 @default.
• W2014501341 cites W2164702862 @default.
• W2014501341 cites W2166549355 @default.
• W2014501341 cites W2170250764 @default.
• W2014501341 cites W2329253404 @default.
• W2014501341 doi "https://doi.org/10.1523/jneurosci.2464-07.2007" @default.
• W2014501341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6673277" @default.
• W2014501341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18032660" @default.
• W2014501341 hasPublicationYear "2007" @default.
• W2014501341 type Work @default.
• W2014501341 sameAs 2014501341 @default.
• W2014501341 citedByCount "63" @default.
• W2014501341 countsByYear W20145013412012 @default.
• W2014501341 countsByYear W20145013412013 @default.
• W2014501341 countsByYear W20145013412014 @default.
• W2014501341 countsByYear W20145013412015 @default.
• W2014501341 countsByYear W20145013412016 @default.
• W2014501341 countsByYear W20145013412017 @default.
• W2014501341 countsByYear W20145013412019 @default.
• W2014501341 countsByYear W20145013412020 @default.
• W2014501341 countsByYear W20145013412021 @default.
• W2014501341 countsByYear W20145013412022 @default.
• W2014501341 countsByYear W20145013412023 @default.
• W2014501341 crossrefType "journal-article" @default.
• W2014501341 hasAuthorship W2014501341A5022103094 @default.
• W2014501341 hasAuthorship W2014501341A5081378606 @default.
• W2014501341 hasBestOaLocation W20145013411 @default.
• W2014501341 hasConcept C104317684 @default.
• W2014501341 hasConcept C130316041 @default.
• W2014501341 hasConcept C134499376 @default.
• W2014501341 hasConcept C143065580 @default.
• W2014501341 hasConcept C146727910 @default.
• W2014501341 hasConcept C148785051 @default.
• W2014501341 hasConcept C169760540 @default.
• W2014501341 hasConcept C170493617 @default.
• W2014501341 hasConcept C181199279 @default.
• W2014501341 hasConcept C187541742 @default.
• W2014501341 hasConcept C200170125 @default.
• W2014501341 hasConcept C203014093 @default.
• W2014501341 hasConcept C204232928 @default.
• W2014501341 hasConcept C2778921374 @default.
• W2014501341 hasConcept C2779201268 @default.
• W2014501341 hasConcept C2781427258 @default.
• W2014501341 hasConcept C2908668639 @default.
• W2014501341 hasConcept C41625074 @default.
• W2014501341 hasConcept C529278444 @default.
• W2014501341 hasConcept C55493867 @default.
• W2014501341 hasConcept C86473631 @default.
• W2014501341 hasConcept C86803240 @default.
• W2014501341 hasConcept C90770895 @default.
• W2014501341 hasConcept C95444343 @default.
• W2014501341 hasConceptScore W2014501341C104317684 @default.
• W2014501341 hasConceptScore W2014501341C130316041 @default.
• W2014501341 hasConceptScore W2014501341C134499376 @default.
• W2014501341 hasConceptScore W2014501341C143065580 @default.
• W2014501341 hasConceptScore W2014501341C146727910 @default.
• W2014501341 hasConceptScore W2014501341C148785051 @default.
• W2014501341 hasConceptScore W2014501341C169760540 @default.
• W2014501341 hasConceptScore W2014501341C170493617 @default.

• next