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- W2014501359 abstract "p53 mutation occurs in over half of all human tumors. Among the remaining tumors, although they may process a wild-type p53, the pathways of p53-induced cell-cycle arrest and apoptosis are deficient. Therefore, p53 serves as a unique molecular target for cancer therapy. This review focuses on the current progress regarding restoration of p53 function in human tumors for molecularly targeted therapy.Targeting p53 for cancer therapy has been intensively pursued. CP-31398 was the first small molecule identified with the ability to restore the wild-type conformation to mutant p53. Subsequently, PRIMA-1 and ellipticine were found to be able to induce mutant p53-dependent cell death. Nutlin was developed to rescue wild-type p53 from degradation mediated by MDM2. More recently, p53 family members can be activated and therefore serve as substitutes of p53 in tumor cells and induce cell death.Loss of p53 function is a characteristic of almost all human tumors. Recent advances demonstrate that reconstitution of p53 function is possible and practical as a promising antitumor strategy." @default.
- W2014501359 created "2016-06-24" @default.
- W2014501359 creator A5028849312 @default.
- W2014501359 creator A5075201353 @default.
- W2014501359 date "2008-01-01" @default.
- W2014501359 modified "2023-09-26" @default.
- W2014501359 title "Restoration of p53 to limit tumor growth" @default.
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- W2014501359 doi "https://doi.org/10.1097/cco.0b013e3282f31d6f" @default.
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