FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014502317> ?p ?o ?g. }

• W2014502317 endingPage "13963" @default.
• W2014502317 startingPage "13952" @default.
• W2014502317 abstract "The Helicobacter pylori CagA protein is translocated into gastric epithelial cells through a type IV secretion system (TFSS), and published studies suggest CagA is critical for H. pylori-associated carcinogenesis. CagA is thought to be necessary and sufficient to induce the motogenic response observed in response to CagA+ strains, as CagA interacts with proteins involved in adhesion and motility. We report that H. pylori strain 60190 stimulated AGS cell motility through a CagA- and TFSS-dependent mechanism, because strains 60190DeltacagA or 60190DeltacagE (TFSS-defective) did not increase motility. The JNK pathway is critical for H. pylori-dependent cell motility, as inhibition using SP600125 (JNK1/2/3 inhibitor) or a JNK2/3-specific inhibitor blocked motility. JNK mediates H. pylori-induced cell motility by activating paxillin, because JNK inhibition blocked paxillinTyr-118 phosphorylation, and paxillin expression knockdown completely abrogated bacteria-induced motility. Furthermore, JNK and paxillinTyr-118 were activated by 60190DeltacagA but not 60190DeltacagE, demonstrating CagA-independent signaling critical for cell motility. A beta1 integrin-blocking antibody significantly inhibited JNK and paxillinTyr-118 phosphorylation and cell scattering, demonstrating that CagA-independent signaling required for cell motility occurs through beta1. The requirement of both Src and focal adhesion kinase for signaling and motility further suggests the importance of integrin signaling in H. pylori-induced cell motility. Finally, we show that JNK activation occurs independent of known upstream kinases and signaling molecules, including Nod1, Cdc42, Rac1, MKK4, and MKK7, which demonstrates novel signaling leading to JNK activation. We report for the first time that H. pylori mediates CagA-independent signaling that promotes cell motility through the beta1 integrin pathway." @default.
• W2014502317 created "2016-06-24" @default.
• W2014502317 creator A5029989647 @default.
• W2014502317 creator A5034627848 @default.
• W2014502317 creator A5074452485 @default.
• W2014502317 creator A5077826580 @default.
• W2014502317 creator A5078839544 @default.
• W2014502317 date "2008-05-01" @default.
• W2014502317 modified "2023-10-16" @default.
• W2014502317 title "The β1 Integrin Activates JNK Independent of CagA, and JNK Activation Is Required for Helicobacter pylori CagA+-induced Motility of Gastric Cancer Cells" @default.
• W2014502317 cites W1483542871 @default.
• W2014502317 cites W1519835538 @default.
• W2014502317 cites W1621166403 @default.
• W2014502317 cites W1638654994 @default.
• W2014502317 cites W1967784629 @default.
• W2014502317 cites W1969202693 @default.
• W2014502317 cites W1969342647 @default.
• W2014502317 cites W1969689864 @default.
• W2014502317 cites W1976083478 @default.
• W2014502317 cites W1979188601 @default.
• W2014502317 cites W1980830316 @default.
• W2014502317 cites W1991444764 @default.
• W2014502317 cites W1993824855 @default.
• W2014502317 cites W1994975655 @default.
• W2014502317 cites W1998051038 @default.
• W2014502317 cites W2000476522 @default.
• W2014502317 cites W2002125536 @default.
• W2014502317 cites W2003035812 @default.
• W2014502317 cites W2007731336 @default.
• W2014502317 cites W2012701265 @default.
• W2014502317 cites W2014119293 @default.
• W2014502317 cites W2024952058 @default.
• W2014502317 cites W2025372731 @default.
• W2014502317 cites W2028936118 @default.
• W2014502317 cites W2031393440 @default.
• W2014502317 cites W2040196938 @default.
• W2014502317 cites W2040443947 @default.
• W2014502317 cites W2040853949 @default.
• W2014502317 cites W2044025776 @default.
• W2014502317 cites W2046454404 @default.
• W2014502317 cites W2053517304 @default.
• W2014502317 cites W2061920676 @default.
• W2014502317 cites W2062132676 @default.
• W2014502317 cites W2076485183 @default.
• W2014502317 cites W2078065785 @default.
• W2014502317 cites W2079989779 @default.
• W2014502317 cites W2086641174 @default.
• W2014502317 cites W2088902653 @default.
• W2014502317 cites W2090681869 @default.
• W2014502317 cites W2094772268 @default.
• W2014502317 cites W2096291329 @default.
• W2014502317 cites W2101366809 @default.
• W2014502317 cites W2108105475 @default.
• W2014502317 cites W2108241942 @default.
• W2014502317 cites W2111183194 @default.
• W2014502317 cites W2111919009 @default.
• W2014502317 cites W2112418598 @default.
• W2014502317 cites W2116757244 @default.
• W2014502317 cites W2118522916 @default.
• W2014502317 cites W2126030299 @default.
• W2014502317 cites W2128576963 @default.
• W2014502317 cites W2134310257 @default.
• W2014502317 cites W2141983035 @default.
• W2014502317 cites W2152588511 @default.
• W2014502317 cites W2156141845 @default.
• W2014502317 cites W2162969038 @default.
• W2014502317 cites W2163791312 @default.
• W2014502317 cites W2163918099 @default.
• W2014502317 cites W2164291683 @default.
• W2014502317 cites W2169852844 @default.
• W2014502317 cites W2299227098 @default.
• W2014502317 doi "https://doi.org/10.1074/jbc.m800289200" @default.
• W2014502317 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2376240" @default.
• W2014502317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18356158" @default.
• W2014502317 hasPublicationYear "2008" @default.
• W2014502317 type Work @default.
• W2014502317 sameAs 2014502317 @default.
• W2014502317 citedByCount "56" @default.
• W2014502317 countsByYear W20145023172012 @default.
• W2014502317 countsByYear W20145023172013 @default.
• W2014502317 countsByYear W20145023172014 @default.
• W2014502317 countsByYear W20145023172015 @default.
• W2014502317 countsByYear W20145023172017 @default.
• W2014502317 countsByYear W20145023172018 @default.
• W2014502317 countsByYear W20145023172019 @default.
• W2014502317 countsByYear W20145023172020 @default.
• W2014502317 countsByYear W20145023172021 @default.
• W2014502317 countsByYear W20145023172022 @default.
• W2014502317 countsByYear W20145023172023 @default.
• W2014502317 crossrefType "journal-article" @default.
• W2014502317 hasAuthorship W2014502317A5029989647 @default.
• W2014502317 hasAuthorship W2014502317A5034627848 @default.
• W2014502317 hasAuthorship W2014502317A5074452485 @default.
• W2014502317 hasAuthorship W2014502317A5077826580 @default.
• W2014502317 hasAuthorship W2014502317A5078839544 @default.
• W2014502317 hasBestOaLocation W20145023171 @default.
• W2014502317 hasConcept C104317684 @default.
• W2014502317 hasConcept C116581196 @default.

• next