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• W2014508949 abstract "Yeast rad3-102, a mutant of the TFIIH complex involved in nucleotide excision repair (NER) and transcription, can perform NER initial steps but not late steps of postincision gap filing. Because removal of early-acting NER proteins prevents rad3-102 deleterious action, we used this feature to explore if chaperones act in early NER. We found that the cochaperone Ydj1 is required for NER and that Ydj1 guarantees TFIIH stoichiometry. Importantly, in the absence of Ydj1, the roles of TFIIH in transcription and transactivation, the ability to activate transcription by nuclear receptors in response to hormones, are strongly impaired. We propose that TFIIH constitutes a multitarget complex for Ydj1, as six of the seven TFIIH core components contain biologically relevant Ydj1- binding motives. Our results provide evidence for a role of chaperones in NER and transcription, with implications in cancer and TFIIH-associated syndromes." @default.
• W2014508949 created "2016-06-24" @default.
• W2014508949 creator A5029702344 @default.
• W2014508949 creator A5030807192 @default.
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• W2014508949 date "2011-08-29" @default.
• W2014508949 modified "2023-10-04" @default.
• W2014508949 title "Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1" @default.
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• W2014508949 doi "https://doi.org/10.1073/pnas.1107425108" @default.
• W2014508949 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3174667" @default.
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