FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014513277> ?p ?o ?g. }

• W2014513277 endingPage "86" @default.
• W2014513277 startingPage "79" @default.
• W2014513277 abstract "Aerial parts of Peganum harmala Linn (APP) is used as traditional medical herb in Uighur medicine in China, and it is traditionally used for treatment of cough and asthma.The aim of the present study is to evaluate the antitussive, expectorant and bronchodilating effects of extract and fractions (alkaloids and flavonoids) from APP, and to support its folk use with scientific evidence, and lay a foundation for its further researches. APP was extracted with 50% ethanol by reflux, extracts were concentrated in vacuum to afford total extract of APP (EXT). EXT was separated to provide alkaloid fraction (ALK) and flavonoid fraction (FLA) by macroporous resin. Antitussive evaluations were carried out with cough models in mice and guinea pigs induced by ammonia liquor, capsaicin, and citric acid. Phenol red secretion experiments in mice were performed to evaluate the expectorant activity. Bronchodilating activities were evaluated with a bronchoconstrictive challenge induced by acetylcholine chloride and histamine in guinea pigs. In all the three antitussive tests, the EXT and ALK could significantly inhibit the frequency of cough, and prolong the cough latent period in animals. High dose of EXT (1650 mg/kg) and ALK (90 mg/kg) in mice and in guinea pigs created therapeutic activities as good as that of codeine phosphate (30 mg/kg). EXT could significantly increase phenol red secretion in mice for 0.64, 1.08 and 1.29 fold averagely at dosages of 183, 550, and 1650 mg/kg, ALK for 0.63, 0.96, 1.06 fold averagely at dosages of 10, 30, and 90 mg/kg, and ammonium chloride (1500 mg/kg, standard expectorant drug) for 0.97 fold, comparing with control group. Aminophylline could dramatically prolong the preconvulsive time for 162.28% in guinea pigs, EXT for 67.34%, 101.96% and 138.00% at dosages of 183, 550, and 1650 mg/kg, ALK for 55.47%, 97.74% and 126.77% at dosages of 10, 30, and 90 mg/kg, and FLA for 84.69%, 95.94% and 154.52% at dosages of 10, 30, and 90 mg/kg, comparing with pretreatment. APP is an effective traditional folk medicine for the treatment of cough with potent antitussive, expectorant and bronchodilating activities. The alkaloid fraction is proved to be the most effective components of APP. The alkaloids from APP may be valuable lead compounds for drug development of respiratory diseases." @default.
• W2014513277 created "2016-06-24" @default.
• W2014513277 creator A5000891681 @default.
• W2014513277 creator A5015800331 @default.
• W2014513277 creator A5016304163 @default.
• W2014513277 creator A5016887977 @default.
• W2014513277 creator A5018680180 @default.
• W2014513277 creator A5020155402 @default.
• W2014513277 creator A5042146352 @default.
• W2014513277 creator A5045433114 @default.
• W2014513277 creator A5066556669 @default.
• W2014513277 creator A5067232975 @default.
• W2014513277 creator A5067337440 @default.
• W2014513277 creator A5071037763 @default.
• W2014513277 date "2015-03-01" @default.
• W2014513277 modified "2023-10-14" @default.
• W2014513277 title "In vivo evaluation of the antitussive, expectorant and bronchodilating effects of extract and fractions from aerial parts of Peganum harmala linn" @default.
• W2014513277 cites W1534049014 @default.
• W2014513277 cites W1956021648 @default.
• W2014513277 cites W1996464155 @default.
• W2014513277 cites W1997517963 @default.
• W2014513277 cites W2016428703 @default.
• W2014513277 cites W2017772358 @default.
• W2014513277 cites W2023018734 @default.
• W2014513277 cites W2037145396 @default.
• W2014513277 cites W2051237707 @default.
• W2014513277 cites W2058757883 @default.
• W2014513277 cites W2059809207 @default.
• W2014513277 cites W2065467204 @default.
• W2014513277 cites W2067939908 @default.
• W2014513277 cites W2073419937 @default.
• W2014513277 cites W2080316056 @default.
• W2014513277 cites W2090126407 @default.
• W2014513277 cites W2091171646 @default.
• W2014513277 cites W2104797123 @default.
• W2014513277 cites W2128528310 @default.
• W2014513277 cites W2141474275 @default.
• W2014513277 cites W2144248157 @default.
• W2014513277 cites W2333826431 @default.
• W2014513277 doi "https://doi.org/10.1016/j.jep.2014.12.046" @default.
• W2014513277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25557031" @default.
• W2014513277 hasPublicationYear "2015" @default.
• W2014513277 type Work @default.
• W2014513277 sameAs 2014513277 @default.
• W2014513277 citedByCount "18" @default.
• W2014513277 countsByYear W20145132772015 @default.
• W2014513277 countsByYear W20145132772016 @default.
• W2014513277 countsByYear W20145132772017 @default.
• W2014513277 countsByYear W20145132772018 @default.
• W2014513277 countsByYear W20145132772019 @default.
• W2014513277 countsByYear W20145132772020 @default.
• W2014513277 countsByYear W20145132772021 @default.
• W2014513277 countsByYear W20145132772022 @default.
• W2014513277 countsByYear W20145132772023 @default.
• W2014513277 crossrefType "journal-article" @default.
• W2014513277 hasAuthorship W2014513277A5000891681 @default.
• W2014513277 hasAuthorship W2014513277A5015800331 @default.
• W2014513277 hasAuthorship W2014513277A5016304163 @default.
• W2014513277 hasAuthorship W2014513277A5016887977 @default.
• W2014513277 hasAuthorship W2014513277A5018680180 @default.
• W2014513277 hasAuthorship W2014513277A5020155402 @default.
• W2014513277 hasAuthorship W2014513277A5042146352 @default.
• W2014513277 hasAuthorship W2014513277A5045433114 @default.
• W2014513277 hasAuthorship W2014513277A5066556669 @default.
• W2014513277 hasAuthorship W2014513277A5067232975 @default.
• W2014513277 hasAuthorship W2014513277A5067337440 @default.
• W2014513277 hasAuthorship W2014513277A5071037763 @default.
• W2014513277 hasConcept C1122143 @default.
• W2014513277 hasConcept C162156334 @default.
• W2014513277 hasConcept C185592680 @default.
• W2014513277 hasConcept C2777389121 @default.
• W2014513277 hasConcept C2777866328 @default.
• W2014513277 hasConcept C2778450494 @default.
• W2014513277 hasConcept C2780237542 @default.
• W2014513277 hasConcept C2909092086 @default.
• W2014513277 hasConcept C43617362 @default.
• W2014513277 hasConcept C556039675 @default.
• W2014513277 hasConcept C71924100 @default.
• W2014513277 hasConcept C98274493 @default.
• W2014513277 hasConceptScore W2014513277C1122143 @default.
• W2014513277 hasConceptScore W2014513277C162156334 @default.
• W2014513277 hasConceptScore W2014513277C185592680 @default.
• W2014513277 hasConceptScore W2014513277C2777389121 @default.
• W2014513277 hasConceptScore W2014513277C2777866328 @default.
• W2014513277 hasConceptScore W2014513277C2778450494 @default.
• W2014513277 hasConceptScore W2014513277C2780237542 @default.
• W2014513277 hasConceptScore W2014513277C2909092086 @default.
• W2014513277 hasConceptScore W2014513277C43617362 @default.
• W2014513277 hasConceptScore W2014513277C556039675 @default.
• W2014513277 hasConceptScore W2014513277C71924100 @default.
• W2014513277 hasConceptScore W2014513277C98274493 @default.
• W2014513277 hasFunder F4320321001 @default.
• W2014513277 hasFunder F4320326675 @default.
• W2014513277 hasFunder F4320327516 @default.
• W2014513277 hasFunder F4320329860 @default.
• W2014513277 hasFunder F4320336020 @default.
• W2014513277 hasLocation W20145132771 @default.
• W2014513277 hasLocation W20145132772 @default.

• next