FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014514571> ?p ?o ?g. }

• W2014514571 endingPage "3065" @default.
• W2014514571 startingPage "3052" @default.
• W2014514571 abstract "Chronic schistosome infection results in the suppression of host immune responses, allowing long-term schistosome survival and restricting pathology. Current theories suggest that Treg play an important role in this regulation. However, the mechanism of Treg induction during schistosome infection is still unknown. The aim of this study was to determine the mechanism behind the induction of CD4(+)CD25(+) T cells by Schistosoma japonicum HSP60 (SjHSP60)-derived peptide SJMHE1 as well as to elucidate the cellular and molecular basis for the induction of CD4(+)CD25(+) T cells during S. japonicum infection. Mice immunized with SJMHE1 or spleen and LN cells from naïve mice pretreated with SJMHE1 in vitro all displayed an increase in CD4(+)CD25(+) T-cell populations. Release of IL-10 and TGF-beta by SJMHE1 stimulation may contribute to suppression. Adoptively transferred SJMHE1-induced CD4(+)CD25(+) T cells inhibited delayed-type hypersensitivity in BALB/c mice. Additionally, SJMHE1-treated APC were tolerogenic and induced CD4(+) cells to differentiate into suppressive CD4(+)CD25(+) Treg. Furthermore, our data support a role for TLR2 in SJMHE1-mediated CD4(+)CD25(+) Treg induction. These findings provide the basis for a more complete understanding of the S. japonicum-host interactions that contribute to host homeostatic mechanisms, preventing an excessive immune response." @default.
• W2014514571 created "2016-06-24" @default.
• W2014514571 creator A5011159487 @default.
• W2014514571 creator A5012008900 @default.
• W2014514571 creator A5016079953 @default.
• W2014514571 creator A5017808282 @default.
• W2014514571 creator A5030976623 @default.
• W2014514571 creator A5057704753 @default.
• W2014514571 creator A5060470951 @default.
• W2014514571 creator A5065621593 @default.
• W2014514571 creator A5074709547 @default.
• W2014514571 creator A5082150667 @default.
• W2014514571 creator A5084138890 @default.
• W2014514571 creator A5091473946 @default.
• W2014514571 date "2009-11-01" @default.
• W2014514571 modified "2023-10-05" @default.
• W2014514571 title "CD4⁺CD25⁺Treg induction by an HSP60-derived peptide SJMHE1 from<i>Schistosoma japonicum</i>is TLR2 dependent" @default.
• W2014514571 cites W110922781 @default.
• W2014514571 cites W1525978917 @default.
• W2014514571 cites W1530782041 @default.
• W2014514571 cites W1536322469 @default.
• W2014514571 cites W1557599311 @default.
• W2014514571 cites W1568165627 @default.
• W2014514571 cites W1601687476 @default.
• W2014514571 cites W1647776454 @default.
• W2014514571 cites W1787048953 @default.
• W2014514571 cites W1911945597 @default.
• W2014514571 cites W1950159513 @default.
• W2014514571 cites W1968276891 @default.
• W2014514571 cites W1968793065 @default.
• W2014514571 cites W1969245192 @default.
• W2014514571 cites W1984942962 @default.
• W2014514571 cites W1992037894 @default.
• W2014514571 cites W1992764003 @default.
• W2014514571 cites W1997105425 @default.
• W2014514571 cites W2003257616 @default.
• W2014514571 cites W2005570998 @default.
• W2014514571 cites W2006283677 @default.
• W2014514571 cites W2012206253 @default.
• W2014514571 cites W2024152763 @default.
• W2014514571 cites W2027618381 @default.
• W2014514571 cites W2035033919 @default.
• W2014514571 cites W2038154111 @default.
• W2014514571 cites W2042964255 @default.
• W2014514571 cites W2047158467 @default.
• W2014514571 cites W2049449911 @default.
• W2014514571 cites W2051024176 @default.
• W2014514571 cites W2053923770 @default.
• W2014514571 cites W2060862592 @default.
• W2014514571 cites W2063679726 @default.
• W2014514571 cites W2065927080 @default.
• W2014514571 cites W2068378145 @default.
• W2014514571 cites W2085628862 @default.
• W2014514571 cites W2088118252 @default.
• W2014514571 cites W2091483766 @default.
• W2014514571 cites W2096973745 @default.
• W2014514571 cites W2097811455 @default.
• W2014514571 cites W2098479780 @default.
• W2014514571 cites W2104357791 @default.
• W2014514571 cites W2110502611 @default.
• W2014514571 cites W2110753254 @default.
• W2014514571 cites W2112027628 @default.
• W2014514571 cites W2112078889 @default.
• W2014514571 cites W2117493229 @default.
• W2014514571 cites W2119275893 @default.
• W2014514571 cites W2121584507 @default.
• W2014514571 cites W2127432084 @default.
• W2014514571 cites W2129767277 @default.
• W2014514571 cites W2130358771 @default.
• W2014514571 cites W2146358021 @default.
• W2014514571 cites W2147858215 @default.
• W2014514571 cites W2153389047 @default.
• W2014514571 cites W2154953543 @default.
• W2014514571 cites W2159275009 @default.
• W2014514571 cites W2159315975 @default.
• W2014514571 cites W2167297241 @default.
• W2014514571 cites W2170677137 @default.
• W2014514571 doi "https://doi.org/10.1002/eji.200939335" @default.
• W2014514571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19882655" @default.
• W2014514571 hasPublicationYear "2009" @default.
• W2014514571 type Work @default.
• W2014514571 sameAs 2014514571 @default.
• W2014514571 citedByCount "58" @default.
• W2014514571 countsByYear W20145145712012 @default.
• W2014514571 countsByYear W20145145712013 @default.
• W2014514571 countsByYear W20145145712014 @default.
• W2014514571 countsByYear W20145145712015 @default.
• W2014514571 countsByYear W20145145712016 @default.
• W2014514571 countsByYear W20145145712017 @default.
• W2014514571 countsByYear W20145145712018 @default.
• W2014514571 countsByYear W20145145712019 @default.
• W2014514571 countsByYear W20145145712020 @default.
• W2014514571 countsByYear W20145145712021 @default.
• W2014514571 countsByYear W20145145712022 @default.
• W2014514571 countsByYear W20145145712023 @default.
• W2014514571 crossrefType "journal-article" @default.
• W2014514571 hasAuthorship W2014514571A5011159487 @default.
• W2014514571 hasAuthorship W2014514571A5012008900 @default.

• next