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• W2014530489 abstract "Equilibrium and kinetic models for nonspecific adsorption of proteins to planar surfaces are presented. These models allow for the possibility of multiple interconvertible surface conformations of adsorbed protein. Steric repulsion resulting in area exclusion by adsorbed molecules is taken into account by treating the adsorbate as a thermodynamically nonideal two-dimensional fluid. In the equilibrium model, the possibility of attractive interactions between adsorbed molecules is taken into account in a limited fashion by permitting one of the adsorbed species to self-associate. Calculated equilibrium adsorption isotherms exhibit apparent high-affinity and low-affinity binding regions, corresponding respectively to adsorption of ligand at low fractional area occupancy in an energetically favorable side-on conformation and conversion at higher fractional area occupancy of the side-on conformation to an entropically favored end-on conformation. Adsorbate self-association may lead to considerable steepening of the adsorption isotherm, compensating to a variable extent for the broadening effect of steric repulsion. Kinetic calculations suggest that in the absence of attractive interactions between adsorbate molecules, the process of adsorption may be highly “stretched” along the time axis, rendering the attainment of adsorption equilibrium in the context of conventional experiments problematic." @default.
• W2014530489 created "2016-06-24" @default.
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• W2014530489 date "1999-01-01" @default.
• W2014530489 modified "2023-10-14" @default.
• W2014530489 title "Adsorption of Globular Proteins on Locally Planar Surfaces. II. Models for the Effect of Multiple Adsorbate Conformations on Adsorption Equilibria and Kinetics" @default.
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• W2014530489 doi "https://doi.org/10.1016/s0006-3495(99)77187-0" @default.
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