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- W2014533284 abstract "Human immunodeficiency virus type 1 (HIV-1)-infected patients (n = 335) in the US Air Force HIV Natural History Program were followed for 3 years (mean) after skin testing, immunophenotyping of CD4+ cell subsets, and measurement of in vitro interleukin-2 production after stimulation by phytohemagglutinin, alloantigens, tetanus toxoid, and influenza A virus. The T cell functional assay predicted survival time (P < .001) and time for progression to AIDS (P = .014). Skin testing for tetanus, mumps, and Candida antigen and the total number of positive tests (P < .001 for each) stratified patients for survival time. In a multivariable proportional hazards model, the T cell functional assay (P = .008), the absolute number of CD4+ T cells (P = .001), the percentage of CD4+ CD29+ cells (P = .06), and the number of reactive skin tests (P < .001) predicted survival time. Thus, cellular immune functional tests have significant predictive value for survival time in HIV-1-infected patients independent of CD4+ cell count." @default.
- W2014533284 created "2016-06-24" @default.
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- W2014533284 date "1995-07-01" @default.
- W2014533284 modified "2023-09-25" @default.
- W2014533284 title "In Vitro T Cell Function, Delayed-Type Hypersensitivity Skin Testing, and CD4+ T Cell Subset Phenotyping Independently Predict Survival Time in Patients Infected with Human Immunodeficiency Virus" @default.
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- W2014533284 doi "https://doi.org/10.1093/infdis/172.1.79" @default.
- W2014533284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7797948" @default.
- W2014533284 hasPublicationYear "1995" @default.