Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014535316> ?p ?o ?g. }
- W2014535316 endingPage "2962" @default.
- W2014535316 startingPage "2957" @default.
- W2014535316 abstract "Epithelial sodium channels (ENaCs) are of immense importance, controlling Na + transport across epithelia and thus playing a central role in all aspects of fluid clearance as well as numerous other functions. Regulation of these channels is critical. Here, we show that haem, a regulator of Na + transport, directly influences ENaC activity, decreasing channel-open probability (but not unitary conductance) in inside-out patches (but not outside-out). Conversely, exposure to the protein in the presence of NADPH and at normoxic O 2 tension (requirements for activity of hemeoxygenase) increases channel activity. CO, a product of hemeoxygenase activity, activated ENaC in a manner similar to that of haem plus NADPH. However, under hypoxic conditions, inhibition of ENaC by haem occurred even in the presence of NADPH. These data demonstrate a potent, O 2 -sensitive mechanism for regulation of ENaC, in which hemeoxygenase acts as the O 2 sensor, its substrate and product inhibiting and stimulating (respectively) the activity of ENaC." @default.
- W2014535316 created "2016-06-24" @default.
- W2014535316 creator A5002093049 @default.
- W2014535316 creator A5056572899 @default.
- W2014535316 creator A5091904163 @default.
- W2014535316 date "2009-02-24" @default.
- W2014535316 modified "2023-10-18" @default.
- W2014535316 title "An oxygen-sensitive mechanism in regulation of epithelial sodium channel" @default.
- W2014535316 cites W1516342639 @default.
- W2014535316 cites W1562084799 @default.
- W2014535316 cites W1588064010 @default.
- W2014535316 cites W1842750594 @default.
- W2014535316 cites W1903443535 @default.
- W2014535316 cites W1964320031 @default.
- W2014535316 cites W1968943030 @default.
- W2014535316 cites W1974297472 @default.
- W2014535316 cites W1982855811 @default.
- W2014535316 cites W1999325366 @default.
- W2014535316 cites W1999554896 @default.
- W2014535316 cites W2023122863 @default.
- W2014535316 cites W2023272006 @default.
- W2014535316 cites W2029938882 @default.
- W2014535316 cites W2030727312 @default.
- W2014535316 cites W2037195552 @default.
- W2014535316 cites W2039079142 @default.
- W2014535316 cites W2041810540 @default.
- W2014535316 cites W2052708978 @default.
- W2014535316 cites W2053649957 @default.
- W2014535316 cites W2057461703 @default.
- W2014535316 cites W2059441862 @default.
- W2014535316 cites W2061545526 @default.
- W2014535316 cites W2072320556 @default.
- W2014535316 cites W2075091287 @default.
- W2014535316 cites W2076563632 @default.
- W2014535316 cites W2083291077 @default.
- W2014535316 cites W2085137108 @default.
- W2014535316 cites W2087499467 @default.
- W2014535316 cites W2093772580 @default.
- W2014535316 cites W2101794714 @default.
- W2014535316 cites W2102495011 @default.
- W2014535316 cites W2109042906 @default.
- W2014535316 cites W2113068746 @default.
- W2014535316 cites W2118709278 @default.
- W2014535316 cites W2127960694 @default.
- W2014535316 cites W2163990363 @default.
- W2014535316 cites W2169789071 @default.
- W2014535316 cites W2176449333 @default.
- W2014535316 cites W2182226952 @default.
- W2014535316 cites W2183587114 @default.
- W2014535316 cites W2312652235 @default.
- W2014535316 cites W2312906472 @default.
- W2014535316 cites W3082816727 @default.
- W2014535316 doi "https://doi.org/10.1073/pnas.0809100106" @default.
- W2014535316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2650320" @default.
- W2014535316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19196957" @default.
- W2014535316 hasPublicationYear "2009" @default.
- W2014535316 type Work @default.
- W2014535316 sameAs 2014535316 @default.
- W2014535316 citedByCount "49" @default.
- W2014535316 countsByYear W20145353162012 @default.
- W2014535316 countsByYear W20145353162013 @default.
- W2014535316 countsByYear W20145353162014 @default.
- W2014535316 countsByYear W20145353162015 @default.
- W2014535316 countsByYear W20145353162016 @default.
- W2014535316 countsByYear W20145353162017 @default.
- W2014535316 countsByYear W20145353162018 @default.
- W2014535316 countsByYear W20145353162019 @default.
- W2014535316 countsByYear W20145353162020 @default.
- W2014535316 countsByYear W20145353162021 @default.
- W2014535316 countsByYear W20145353162022 @default.
- W2014535316 crossrefType "journal-article" @default.
- W2014535316 hasAuthorship W2014535316A5002093049 @default.
- W2014535316 hasAuthorship W2014535316A5056572899 @default.
- W2014535316 hasAuthorship W2014535316A5091904163 @default.
- W2014535316 hasBestOaLocation W20145353162 @default.
- W2014535316 hasConcept C104317684 @default.
- W2014535316 hasConcept C12554922 @default.
- W2014535316 hasConcept C127561419 @default.
- W2014535316 hasConcept C178790620 @default.
- W2014535316 hasConcept C185592680 @default.
- W2014535316 hasConcept C50952357 @default.
- W2014535316 hasConcept C537181965 @default.
- W2014535316 hasConcept C55493867 @default.
- W2014535316 hasConcept C6507245 @default.
- W2014535316 hasConcept C6929976 @default.
- W2014535316 hasConcept C86803240 @default.
- W2014535316 hasConcept C95444343 @default.
- W2014535316 hasConceptScore W2014535316C104317684 @default.
- W2014535316 hasConceptScore W2014535316C12554922 @default.
- W2014535316 hasConceptScore W2014535316C127561419 @default.
- W2014535316 hasConceptScore W2014535316C178790620 @default.
- W2014535316 hasConceptScore W2014535316C185592680 @default.
- W2014535316 hasConceptScore W2014535316C50952357 @default.
- W2014535316 hasConceptScore W2014535316C537181965 @default.
- W2014535316 hasConceptScore W2014535316C55493867 @default.
- W2014535316 hasConceptScore W2014535316C6507245 @default.
- W2014535316 hasConceptScore W2014535316C6929976 @default.
- W2014535316 hasConceptScore W2014535316C86803240 @default.